Analyzing Large-Scale Samples Confirms the Association Between the ABCA7 rs3764650 Polymorphism and Alzheimer's Disease Susceptibility

	Analyzing Large-Scale Samples Confirms the Association Between the ABCA7 rs3764650 Polymorphism and Alzheimer's Disease Susceptibility
	Liu, Guiyou 1,2; Li, Fujun 3; Zhang, Shuyan 4; Jiang, Yongshuai 5; Ma, Guoda 1; Shang, Hong 4; Liu, Jiafeng 6; Feng, Rennan 7; Zhang, Liangcai 8; Liao, Mingzhi 5
刊名	MOLECULAR NEUROBIOLOGY
	2014-12-01
卷号	50 期号:3 页码:757-764
关键词	ABCA7 rs3764650 polymorphism Alzheimer's disease Genome-wide association studies
英文摘要	Large-scale genome-wide association studies (GWAS) have revealed that the ABCA7 rs3764650 polymorphism (or its proxies, namely rs115550680, rs3752246, and rs4147929) is associated with Alzheimer's disease (AD) susceptibility in individuals of Caucasian ancestry. The following studies have investigated this finding in Chinese (N=633 and N=1,224), Japanese (N=1,735), Korean (N=844), African American (N=5,896), and Canadian (N=1,104) populations. However, these studies reported a weak or negligible association. We hypothesized that these negative results may have been caused by either relatively small sample sizes compared with those used for the previous GWAS in individuals of Caucasian ancestry or the genetic heterogeneity of the rs3764650 polymorphism (or its proxies) in different populations. Here, we reevaluated the association between rs3764650 and AD using large-scale samples from 18 previous studies (N=79,381-30,590 cases and 48,791 controls) by searching PubMed, AlzGene, and Google Scholar databases. Using allele, dominant, recessive, and additive models, we did not identify significant heterogeneity among the 18 studies. We observed a significant association between rs3764650 and AD using the allele (P=1.76E-26, odds ratio (OR)=1.21, 95% confidence interval (CI) 1.17-1.26), dominant (P=4.00E-04, OR=1.17, 95% CI 1.07-1.28), recessive (P=3.00E-03, OR=1.43, 95% CI 1.13-1.81), and additive models (P=3.00E-03, OR=1.49, 95 % CI 1.16-1.91). Collectively, our analysis further supports previous findings that the ABCA7 rs3764650 polymorphism is associated with AD susceptibility. We believe that our findings will be very useful for future genetic studies on AD.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	GENOME-WIDE ASSOCIATION ; GENETIC ASSOCIATION ; IDENTIFIES VARIANTS ; AFRICAN-AMERICANS ; COMMON VARIANTS ; POPULATION ; LOCI ; CLU ; METAANALYSIS ; CD2AP
收录类别	SCI
语种	英语
WOS记录号	WOS:000344865700004
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/1366]
专题	天津工业生物技术研究所_基因组分析实验室陈祖耕_期刊论文
作者单位	1.Guangdong Med Coll, Inst Neurol, Zhanjiang 524001, Peoples R China 2.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Tianjin Airport Econ Area, Tianjin 300308, Peoples R China 3.Harbin Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Harbin, Peoples R China 4.Harbin Med Univ, Affiliated Hosp 4, Dept Neurol, Harbin, Peoples R China 5.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China 6.First Hosp Harbin, Dept Neurol, Harbin, Peoples R China 7.Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Harbin, Peoples R China 8.Rice Univ, Dept Stat, Houston, TX 77251 USA 9.Guangdong Med Coll, Affiliated Hosp, Key Lab Aging Related Cardiocerebral Dis Guangdon, Zhanjiang, Peoples R China
推荐引用方式 GB/T 7714	Liu, Guiyou,Li, Fujun,Zhang, Shuyan,et al. Analyzing Large-Scale Samples Confirms the Association Between the ABCA7 rs3764650 Polymorphism and Alzheimer's Disease Susceptibility[J]. MOLECULAR NEUROBIOLOGY,2014,50(3):757-764.
APA	Liu, Guiyou.,Li, Fujun.,Zhang, Shuyan.,Jiang, Yongshuai.,Ma, Guoda.,...&Li, Keshen.(2014).Analyzing Large-Scale Samples Confirms the Association Between the ABCA7 rs3764650 Polymorphism and Alzheimer's Disease Susceptibility.MOLECULAR NEUROBIOLOGY,50(3),757-764.
MLA	Liu, Guiyou,et al."Analyzing Large-Scale Samples Confirms the Association Between the ABCA7 rs3764650 Polymorphism and Alzheimer's Disease Susceptibility".MOLECULAR NEUROBIOLOGY 50.3(2014):757-764.