Cardiovascular disease contributes to Alzheimer's disease: evidence from large-scale genome-wide association studies

	Cardiovascular disease contributes to Alzheimer's disease: evidence from large-scale genome-wide association studies
	Liu, Guiyou 1,2; Yao, Lifen 3; Liu, Jiafeng 4; Jiang, Yongshuai 5; Ma, Guoda 1; Chen, Zugen 6; Zhao, Bin 7; Li, Keshen 1,7; Genetic Environm Risk Alzheimer's
刊名	NEUROBIOLOGY OF AGING
	2014-04-01
卷号	35 期号:4 页码:786-792
关键词	Alzheimer's disease Cardiovascular disease Pathway analysis Genome-wide association studies
英文摘要	Alzheimer's disease (AD) is the most common and complex neurodegenerative disease in the elderly individuals. Recently, genome-wide association studies (GWAS) have been used to investigate AD pathogenesis. These GWAS have yielded important new insights into the genetic mechanisms of AD. However, these newly identified AD susceptibility loci exert only very small risk effects and cannot fully explain the underlying AD genetic risk. We hypothesize that combining the findings from different AD GWAS may have greater power than genetic analysis alone. To identify new AD risk factors, we integrated findings from 3 previous large-scale AD GWAS (n = 14,138) using a gene-based meta-analysis and subsequently conducted a pathway analysis using the kyoto encyclopedia of genes and genomes and gene ontology databases. Interestingly, we not only confirmed previous findings, but also highlighted, for the first time, the involvement of cardiovascular disease-related pathways in AD. Our results provided the clues as to the link between these diseases using pathway analysis methods. We believe that these findings will be very useful for future genetic studies of AD. (C) 2014 Elsevier Inc. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Geriatrics & Gerontology ; Neurosciences
研究领域[WOS]	Geriatrics & Gerontology ; Neurosciences & Neurology
关键词[WOS]	VASCULAR RISK-FACTORS ; HEART-FAILURE ; DILATED CARDIOMYOPATHY ; IDENTIFIES VARIANTS ; PATHWAY ANALYSIS ; COMMON VARIANTS ; GENE ; PROGRESSION ; MYOCARDITIS ; POPULATION
收录类别	SCI
语种	英语
WOS记录号	WOS:000330283300009
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/1341]
专题	天津工业生物技术研究所_基因组分析实验室陈祖耕_期刊论文
作者单位	1.Guangdong Med Coll, Inst Neurol, Zhanjiang 524001, Guangdong, Peoples R China 2.Chinese Acad Sci, Genome Anal Lab, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China 3.Harbin Med Univ, Affiliated Hosp 1, Dept Neurol, Harbin, Heilongjiang, Peoples R China 4.First Hosp Harbin, Dept Neurol, Harbin, Heilongjiang, Peoples R China 5.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Heilongjiang, Peoples R China 6.Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA 7.Guangdong Med Coll, Affiliated Hosp, Key Lab Aging Related Cardiocerebral Dis Guangdon, Zhanjiang, Peoples R China
推荐引用方式 GB/T 7714	Liu, Guiyou,Yao, Lifen,Liu, Jiafeng,et al. Cardiovascular disease contributes to Alzheimer's disease: evidence from large-scale genome-wide association studies[J]. NEUROBIOLOGY OF AGING,2014,35(4):786-792.
APA	Liu, Guiyou.,Yao, Lifen.,Liu, Jiafeng.,Jiang, Yongshuai.,Ma, Guoda.,...&Genetic Environm Risk Alzheimer's.(2014).Cardiovascular disease contributes to Alzheimer's disease: evidence from large-scale genome-wide association studies.NEUROBIOLOGY OF AGING,35(4),786-792.
MLA	Liu, Guiyou,et al."Cardiovascular disease contributes to Alzheimer's disease: evidence from large-scale genome-wide association studies".NEUROBIOLOGY OF AGING 35.4(2014):786-792.