BIN1 gene rs744373 polymorphism contributes to Alzheimer's disease in East Asian population

	BIN1 gene rs744373 polymorphism contributes to Alzheimer's disease in East Asian population
	Liu, Guiyou 1,2; Zhang, Shuyan 3; Cai, Zhiyou 1; Li, You 1; Cui, Lili 1; Ma, Guoda 1; Jiang, Yongshuai 4; Zhang, Liangcai 4; Feng, Rennan 5; Liao, Mingzhi 4
刊名	NEUROSCIENCE LETTERS
	2013-06-07
卷号	544 页码:47-51
关键词	Genome-wide association studies BIN1 gene rs744373 polymorphism East Asian Caucasian
英文摘要	Large-scale genome-wide association studies (GWAS) identified BIN1 gene rs744373 polymorphism to be significantly associated with Alzheimer's disease (AD) in Caucasian ancestry. Recently, this polymorphism was also investigated in East Asian population. However, no study reported significant association. We consider that the failure to replicate significant association between rs744373 polymorphism and AD may be caused by the relatively small sample size. In this research, we evaluated this association using pooled samples from previous studies (n = 4982, 1437 AD cases and 3545 controls). Two methods including pooled analysis and meta-analysis were used to investigate the association. Using the pooled analysis, we observed significant association between rs744373 polymorphism and AD by both genotype test (P = 3.94E-03, 4.59E-03 and 1.04E-02) and allele test (P = 1.12E-03, OR = 1.16, 95% CI 1.06-1.28). Interestingly, the meta-analysis confirmed this association with P = 8.00E-03 (OR = 1.14, 95% CI 1.03-1.25) and P = 2.00E-02 (OR = 1.16, 95% CI 1.02-1.32). We also evaluated the effect of rs744373 polymorphism on AD risk in different ethnic backgrounds and found that rs744373 polymorphism contributed to AD with similar genetic risk in East Asian and Caucasian populations. To our knowledge, this is the first study to show significant association between rs744373 polymorphism and AD in East Asian population. (c) 2013 Elsevier Ireland Ltd. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	GENOME-WIDE ASSOCIATION ; IDENTIFIES VARIANTS ; COMMON VARIANTS ; CD2AP ; EPHA1 ; CD33 ; CLU
收录类别	SCI
语种	英语
WOS记录号	WOS:000320632300010
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/1258]
专题	天津工业生物技术研究所_基因组分析实验室陈祖耕_期刊论文
作者单位	1.Guangdong Med Coll, Inst Neurol, Zhanjiang 524001, Peoples R China 2.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Genome Anal Lab, Beijing 100864, Peoples R China 3.Harbin Med Univ, Affiliated Hosp 4, Dept Neurol, Harbin 150001, Peoples R China 4.Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin, Peoples R China 5.Harbin Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Harbin, Peoples R China 6.Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA 7.Guangdong Med Coll, Affiliated Hosp, Guangdong Key Lab Age Related Cardiac & Cerebral, Zhanjiang 524001, Peoples R China
推荐引用方式 GB/T 7714	Liu, Guiyou,Zhang, Shuyan,Cai, Zhiyou,et al. BIN1 gene rs744373 polymorphism contributes to Alzheimer's disease in East Asian population[J]. NEUROSCIENCE LETTERS,2013,544:47-51.
APA	Liu, Guiyou.,Zhang, Shuyan.,Cai, Zhiyou.,Li, You.,Cui, Lili.,...&Li, Keshen.(2013).BIN1 gene rs744373 polymorphism contributes to Alzheimer's disease in East Asian population.NEUROSCIENCE LETTERS,544,47-51.
MLA	Liu, Guiyou,et al."BIN1 gene rs744373 polymorphism contributes to Alzheimer's disease in East Asian population".NEUROSCIENCE LETTERS 544(2013):47-51.