Transepithelial Transports of Rare Sugar D-Psicose in Human Intestine | |
Hishiike, Takashi1; Ogawa, Masahiro1; Hayakawa, Shigeru1; Nakajima, Daichi1; O'Charoen, Siwaporn1; Ooshima, Hisaka2; Sun, Yuanxia1,3 | |
刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2013-07-31 | |
卷号 | 61期号:30页码:7381-7386 |
关键词 | Caco-2 rare sugar GLUT5 GLUT2 |
英文摘要 | D-Psicose (Psi), the C3-epimer of D-fructose (Fru), is a noncalorie sugar with a lower glycemic response. The trans-cellular pathway of Psi in human enterocytes was investigated using a Caco-2 cell monolayer. The permeation rate of Psi across the monolayer was not affected by the addition of phlorizin, an inhibitor of sugar transporter SGLT1, whereas it was accelerated by treatment with forskolin, a GLUT5-gene inducer, clearly showing that GLUT5 is involved in the transport of Psi. The permeability of Psi was suppressed in the presence of D-glucose (Glc) and Fru, suggesting that the three monosaccharides are transported via the same transporter. Since GLUT2, the predominant sugar transporter on the basolateral membrane of enterocytes, mediates the transport of Glc and Fru, Psi might be mediated by GLUT2. The present study shows that Psi is incorporated from the intestinal lumen into enterocytes via GLUT5 and is released to the lamina propria via GLUT2. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
类目[WOS] | Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology |
研究领域[WOS] | Agriculture ; Chemistry ; Food Science & Technology |
关键词[WOS] | D-TAGATOSE 3-EPIMERASE ; D-ALLOSE ; GLUCOSE-TRANSPORTER ; CACO-2 CELLS ; RATS ; FRUCTOSE ; SYSTEM ; PHLORHIZIN ; SUPPRESSES ; HEXOSE |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000322752700027 |
内容类型 | 期刊论文 |
源URL | [http://124.16.173.210/handle/834782/1275] ![]() |
专题 | 天津工业生物技术研究所_功能糖与天然活性物质研究组 孙媛霞 _期刊论文 |
作者单位 | 1.Kagawa Univ, Fac Agr, Dept Appl Biol Sci, Miki, Kagawa 7610795, Japan 2.Kagawa Prefectural Ind Technol Ctr, Fermentat & Food Res Branch, Shodoshima, Kagawa 7614421, Japan 3.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Natl Engn Lab Ind Enzymes, Tianjin 300308, Peoples R China |
推荐引用方式 GB/T 7714 | Hishiike, Takashi,Ogawa, Masahiro,Hayakawa, Shigeru,et al. Transepithelial Transports of Rare Sugar D-Psicose in Human Intestine[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2013,61(30):7381-7386. |
APA | Hishiike, Takashi.,Ogawa, Masahiro.,Hayakawa, Shigeru.,Nakajima, Daichi.,O'Charoen, Siwaporn.,...&Sun, Yuanxia.(2013).Transepithelial Transports of Rare Sugar D-Psicose in Human Intestine.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,61(30),7381-7386. |
MLA | Hishiike, Takashi,et al."Transepithelial Transports of Rare Sugar D-Psicose in Human Intestine".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 61.30(2013):7381-7386. |
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