Transepithelial Transports of Rare Sugar D-Psicose in Human Intestine

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	Transepithelial Transports of Rare Sugar D-Psicose in Human Intestine
	Hishiike, Takashi 1; Ogawa, Masahiro 1; Hayakawa, Shigeru 1; Nakajima, Daichi 1; O'Charoen, Siwaporn 1; Ooshima, Hisaka 2; Sun, Yuanxia 1,3
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2013-07-31
卷号	61 期号:30 页码:7381-7386
关键词	Caco-2 rare sugar GLUT5 GLUT2
英文摘要	D-Psicose (Psi), the C3-epimer of D-fructose (Fru), is a noncalorie sugar with a lower glycemic response. The trans-cellular pathway of Psi in human enterocytes was investigated using a Caco-2 cell monolayer. The permeation rate of Psi across the monolayer was not affected by the addition of phlorizin, an inhibitor of sugar transporter SGLT1, whereas it was accelerated by treatment with forskolin, a GLUT5-gene inducer, clearly showing that GLUT5 is involved in the transport of Psi. The permeability of Psi was suppressed in the presence of D-glucose (Glc) and Fru, suggesting that the three monosaccharides are transported via the same transporter. Since GLUT2, the predominant sugar transporter on the basolateral membrane of enterocytes, mediates the transport of Glc and Fru, Psi might be mediated by GLUT2. The present study shows that Psi is incorporated from the intestinal lumen into enterocytes via GLUT5 and is released to the lamina propria via GLUT2.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences
类目[WOS]	Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
研究领域[WOS]	Agriculture ; Chemistry ; Food Science & Technology
关键词[WOS]	D-TAGATOSE 3-EPIMERASE ; D-ALLOSE ; GLUCOSE-TRANSPORTER ; CACO-2 CELLS ; RATS ; FRUCTOSE ; SYSTEM ; PHLORHIZIN ; SUPPRESSES ; HEXOSE
收录类别	SCI
语种	英语
WOS记录号	WOS:000322752700027
内容类型	期刊论文
源URL	[http://124.16.173.210/handle/834782/1275]
专题	天津工业生物技术研究所_功能糖与天然活性物质研究组孙媛霞 _期刊论文
作者单位	1.Kagawa Univ, Fac Agr, Dept Appl Biol Sci, Miki, Kagawa 7610795, Japan 2.Kagawa Prefectural Ind Technol Ctr, Fermentat & Food Res Branch, Shodoshima, Kagawa 7614421, Japan 3.Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Natl Engn Lab Ind Enzymes, Tianjin 300308, Peoples R China
推荐引用方式 GB/T 7714	Hishiike, Takashi,Ogawa, Masahiro,Hayakawa, Shigeru,et al. Transepithelial Transports of Rare Sugar D-Psicose in Human Intestine[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2013,61(30):7381-7386.
APA	Hishiike, Takashi.,Ogawa, Masahiro.,Hayakawa, Shigeru.,Nakajima, Daichi.,O'Charoen, Siwaporn.,...&Sun, Yuanxia.(2013).Transepithelial Transports of Rare Sugar D-Psicose in Human Intestine.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,61(30),7381-7386.
MLA	Hishiike, Takashi,et al."Transepithelial Transports of Rare Sugar D-Psicose in Human Intestine".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 61.30(2013):7381-7386.