The potential cytotoxicity and mechanism of VO2 thin films for intelligent thermochromic windows

CORC > 上海硅酸盐研究所 > 中国科学院上海硅酸盐研究所 > 古陶瓷与工业陶瓷工程研究中心 > 期刊论文

	The potential cytotoxicity and mechanism of VO2 thin films for intelligent thermochromic windows
	Zhou, Huaijuan 1,2; Li, Jinhua 1,2; Bao, Shanhu 1; Wang, Donghui 1,2; Liu, Xuanyong 1; Jin, Ping 1,3
刊名	RSC ADVANCES
	2015
卷号	5 期号:129 页码:106315-106324
英文摘要	A thermochromic vanadium dioxide (VO2) film holds great promise for intelligent windows owing to marvelous semiconductor-metal transitions (SMT), an active response to external temperature stimuli and near-infrared irradiation. To date, however, its potential biological effect on human cells has not been well characterized. In this work, homogeneous high quality VO2 films with different thicknesses (30, 80, 120 nm) were prepared on a quartz glass substrate. Afterwards, for the first time, we demonstrate the time-dependent and dose-dependent cytotoxicity of the VO2 film to human cells. Speciation analysis by V-51 NMR spectra and surface zeta potentials revealed the formation of vanadate(+5) and ADPV, an analogue of ATP. On the basis of energy metabolism or bioenergetics, a plausible hypothesis, i.e., "ATP dyssynthesis", is proposed here to elucidate the potential toxicity mechanism of the VO2 nanomaterial via vanadate-phosphate antagonism including two steps: (i) vanadate speciation from VO2 surface chemistry; (ii) vanadate disturbing ATP synthesis as a phosphate analogue. ATP stores energy to carry out various life processes; once its synthesis is hindered, vital movement will be impaired. From the perspective of surface modification and bioactivation, some practical methods are recommended to compensate for the potential cytotoxicity of the VO2 material. We expect this work can stimulate scientific interest to search for more versatile material design strategies to balance the energy-saving efficiency and environmental safety of VO2 intelligent window coatings.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	VANADIUM COMPOUNDS ; OXIDATIVE STRESS ; FREE-RADICALS ; VANADATE ; TOXICITY ; INTERFACE ; CELL ; MITOCHONDRIA ; COMPLEXATION ; NUCLEOSIDES
收录类别	SCI
语种	英语
WOS记录号	WOS:000367274300005
内容类型	期刊论文
源URL	[http://ir.sic.ac.cn/handle/331005/7956]
专题	上海硅酸盐研究所_古陶瓷与工业陶瓷工程研究中心_期刊论文
作者单位	1.Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Natl Inst Adv Ind Sci & Technol, Mat Res Inst Sustainable Dev, Nagoya, Aichi 4638560, Japan
推荐引用方式 GB/T 7714	Zhou, Huaijuan,Li, Jinhua,Bao, Shanhu,et al. The potential cytotoxicity and mechanism of VO2 thin films for intelligent thermochromic windows[J]. RSC ADVANCES,2015,5(129):106315-106324.
APA	Zhou, Huaijuan,Li, Jinhua,Bao, Shanhu,Wang, Donghui,Liu, Xuanyong,&Jin, Ping.(2015).The potential cytotoxicity and mechanism of VO2 thin films for intelligent thermochromic windows.RSC ADVANCES,5(129),106315-106324.
MLA	Zhou, Huaijuan,et al."The potential cytotoxicity and mechanism of VO2 thin films for intelligent thermochromic windows".RSC ADVANCES 5.129(2015):106315-106324.