Bioactive spirostane glycosides from Tacca plantaginea

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Bioactive spirostane glycosides from Tacca plantaginea
	Liu, Zhen-Hua 1,2; Yan, Huan 1; Si, Yong-Ai1,2 ; Ni, Wei 1; Chen, Yu 1,2; He, Li 3; Liu, Hai-Yang1
刊名	STEROIDS
	2016-02-01
卷号	106 页码:86-92
关键词	Tacca plantaginea Spirostane glycosides Taccaosides E-L Cytotoxicity Induced platelet aggregation activity
英文摘要	Eight new spirostane glycosides, taccaosides E-L (2-7, 11, and 14), along with 7 known spirostane glycosides were isolated from the extract of the whole plants of Tacca plantaginea (Hance) Drenth. Their structures were established on the basis of physical data, spectroscopic analysis (MS, 1D and 2D NMR), and chemical methods. The cytotoxicities of the isolates were evaluated in vitro against two human cancer cell lines (HEK293 and HepG2). The results showed that compound 1 had the strongest cytotoxic activity with IC50 values of 1.7 mu M and 1.2 mu M against the two cancer cell lines, respectively. Furthermore, the spirostane glycosides with 17 alpha-hydroxyl group at their aglycones (10, 12, and 15) were tested for the induced platelet aggregation activity. (C) 2015 Elsevier Inc. All rights reserved.
类目[WOS]	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]	STEROIDAL SAPONINS ; BLOOD-PLATELETS ; AGGREGATION ; RHIZOMES
收录类别	SCI
语种	英语
WOS记录号	WOS:000371191000011
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/25981]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Kunming Med Univ, Affiliated Hosp 1, Dept Dermatol, Kunming 650032, Peoples R China
推荐引用方式 GB/T 7714	Liu, Zhen-Hua,Yan, Huan,Si, Yong-Ai,et al. Bioactive spirostane glycosides from Tacca plantaginea[J]. STEROIDS,2016,106:86-92.
APA	Liu, Zhen-Hua.,Yan, Huan.,Si, Yong-Ai.,Ni, Wei.,Chen, Yu.,...&Liu, Hai-Yang.(2016).Bioactive spirostane glycosides from Tacca plantaginea.STEROIDS,106,86-92.
MLA	Liu, Zhen-Hua,et al."Bioactive spirostane glycosides from Tacca plantaginea".STEROIDS 106(2016):86-92.