Altered Value Coding in the Ventromedial Prefrontal Cortex in Healthy Older Adults

CORC > 心理研究所 > 中国科学院心理研究所 > 中国科学院心理健康重点实验室

	Altered Value Coding in the Ventromedial Prefrontal Cortex in Healthy Older Adults
	Yu, Jing1,2,3 ; Mamerow, Loreen 2; Lei, Xu 1; Fang, Lei 4; Mata, Rui 2,5; Jing Yu
刊名	FRONTIERS IN AGING NEUROSCIENCE
	2016-08-31
通讯作者邮箱	helen12@swu.edu.cn
卷号	8 期号:0 页码:1-15
关键词	aging decision making ventromedial prefrontal cortex anterior insula Balloon Analogue Risk Task
ISSN号	1663-4365
通讯作者	Jing Yu
英文摘要	Previous work suggests that aging is associated with changes in risk taking but less is known about their underlying neural basis, such as the potential age differences in the neural processing of value and risk. The goal of the present study was to investigate adult age differences in functional neural responses in a naturalistic risk-taking task. Twenty-six young adults and 27 healthy older adults completed the Balloon Analogue Risk Task while undergoing functional magnetic resonance imaging. Young and older adults showed similar overt risk-taking behavior. Group comparison of neural activity in response to risky vs. control stimuli revealed similar patterns of activation in the bilateral striatum, anterior insula (AI) and ventromedial prefrontal cortex (vmPFC). Group comparison of parametrically modulated activity in response to continued pumping similarly revealed comparable results for both age groups in the AI and, potentially, the striatum, yet differences emerged for regional activity in the vmPFC. At whole brain level, insular, striatal and vmPFC activation was predictive of behavioral risk taking for young but not older adults. The current results are interpreted and discussed as preserved neural tracking of risk and reward in the AI and striatum, respectively, but altered value coding in the vmPFC in the two age groups. The latter finding points toward older adults exhibiting differential vmPFC-related integration and value coding. Furthermore, neural activation holds differential predictive validity for behavioral risk taking in young and older adults.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Geriatrics & Gerontology ; Neurosciences
研究领域[WOS]	Geriatrics & Gerontology ; Neurosciences & Neurology
关键词[WOS]	ANALOG-RISK-TASK ; REWARD PREDICTION ERRORS ; IOWA GAMBLING TASK ; DECISION-MAKING ; INDIVIDUAL-DIFFERENCES ; AGE-DIFFERENCES ; TAKING PROPENSITY ; NEURAL BASIS ; CHOICE ; BRAIN
收录类别	SCI ; SSCI
语种	英语
WOS记录号	WOS:000382354300004
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/20534]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Jing Yu
作者单位	1.Southwest Univ, Fac Psychol, Chongqing, Peoples R China 2.Univ Basel, Dept Cognit & Decis Sci, Basel, Switzerland 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 4.Southeast Univ, Fac Med, Nanjing, Jiangsu, Peoples R China 5.Max Planck Inst Human Dev, Berlin, Germany
推荐引用方式 GB/T 7714	Yu, Jing,Mamerow, Loreen,Lei, Xu,et al. Altered Value Coding in the Ventromedial Prefrontal Cortex in Healthy Older Adults[J]. FRONTIERS IN AGING NEUROSCIENCE,2016,8(0):1-15.
APA	Yu, Jing,Mamerow, Loreen,Lei, Xu,Fang, Lei,Mata, Rui,&Jing Yu.(2016).Altered Value Coding in the Ventromedial Prefrontal Cortex in Healthy Older Adults.FRONTIERS IN AGING NEUROSCIENCE,8(0),1-15.
MLA	Yu, Jing,et al."Altered Value Coding in the Ventromedial Prefrontal Cortex in Healthy Older Adults".FRONTIERS IN AGING NEUROSCIENCE 8.0(2016):1-15.