Mechanisms of Microcystin-induced Cytotoxicity and Apoptosis

CORC > 水生生物研究所 > 中科院水生所知识产出（2009年前） > 水生生物多样性与资源保护研究中心 > 学位论文

	Mechanisms of Microcystin-induced Cytotoxicity and Apoptosis
	Chen, Liang 1,2; Xie, Ping 1
刊名	MINI-REVIEWS IN MEDICINAL CHEMISTRY
	2016
卷号	16 期号:13 页码:1018-1031
关键词	Apoptosis cell death cytoskeleton genotoxicity microcystin mitochondria oxidative stress protein phosphatase
ISSN号	1389-5575
英文摘要	In recent years, cyanobacterial blooms have dramatically increased and become an ecological disaster worldwide. Cyanobacteria are also known to produce a wide variety of toxic secondary metabolites, i.e. cyanotoxins. Microcystins (MCs), a group of cyclic heptapeptides, are considered to be one of the most common and dangerous cyanobacterial toxins. MCs can be incorporated into the cells via organic anion transporting polypeptides (Oatps). It's widely accepted that inhibition of protein phosphatases (PPs) and induction of oxidative stress are the main toxic mechanisms of MCs. MCs are able to induce a variety of toxic cellular effects, including DNA damage, cytoskeleton disruption, mitochondria dysfunction, endoplasmic reticulum (ER) disturbance and cell cycle deregulation, all of which can contribute to apoptosis/programmed cell death. This review aimed to summarize the increasing data regarding the intracellular biochemical and molecular mechanisms of MC-induced toxicity and cell death.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Chemistry, Medicinal
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	INDUCED DNA-DAMAGE ; MITOCHONDRIAL PERMEABILITY TRANSITION ; CULTURED RAT HEPATOCYTES ; ZEBRAFISH DANIO-RERIO ; INDUCED CELL-DEATH ; INDUCED CYTOSKELETAL REORGANIZATION ; NEUROENDOCRINE PC12 CELLS ; AMNIOTIC EPITHELIAL-CELLS ; PROTEIN PHOSPHATASE 2A ; LYMPHOCYTES IN-VITRO
收录类别	SCI
语种	英语
WOS记录号	WOS:000382300300002
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/28352]
专题	水生生物研究所_水生生物多样性与资源保护研究中心_学位论文
作者单位	1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Donghu Expt Stn Lake Ecosyst, Wuhan 430072, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Chen, Liang,Xie, Ping. Mechanisms of Microcystin-induced Cytotoxicity and Apoptosis[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY,2016,16(13):1018-1031.
APA	Chen, Liang,&Xie, Ping.(2016).Mechanisms of Microcystin-induced Cytotoxicity and Apoptosis.MINI-REVIEWS IN MEDICINAL CHEMISTRY,16(13),1018-1031.
MLA	Chen, Liang,et al."Mechanisms of Microcystin-induced Cytotoxicity and Apoptosis".MINI-REVIEWS IN MEDICINAL CHEMISTRY 16.13(2016):1018-1031.