African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction

	African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction
	Levran, Orna 1; Randesi, Matthew 1; Peles, Einat 2,3; da Rosa, Joel Correa 4; Ott, Jurg 5,6; Rotrosen, John 7,8; Adelson, Miriam 1,2,9; Kreek, Mary Jeanne 1
刊名	PHARMACOGENOMICS
	2016-06-01
通讯作者邮箱	levrano@rockefeller.edu
卷号	17 期号:9 页码:995-1003
关键词	African ancestry cholinergic receptors CHRM4 cocaine addiction opioid addiction
ISSN号	1462-2416
通讯作者	Levran, Orna
英文摘要	Aim: This study was designed to determine whether polymorphisms in acetylcholine receptors contribute to opioid dependence and/or cocaine dependence. Patients & methods: The sample (n = 1860) was divided by drug and ancestry, and 55 polymorphisms (nine genes) were analyzed. Results: Of the 20 SNPs that showed nominally significant associations, the association of the African-specific CHRM4 SNP rs2229163 (Asn417=) with cocaine dependence survived correction for multiple testing (P-corrected = 0.047). CHRM4 is located in a region of strong linkage disequilibrium on chromosome 11 that includes genes associated with schizophrenia. CHRM4 SNP rs2229163 is in strong linkage disequilibrium with several African- specific SNPs in DGKZ and AMBRA1. Conclusion: Cholinergic receptors' variants may contribute to drug addiction and have a potential role as pharmacogenetic markers.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Pharmacology & Pharmacy
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	NICOTINE DEPENDENCE ; CHRM2 GENE ; ALCOHOL DEPENDENCE ; NUCLEUS-ACCUMBENS ; DRUG-DEPENDENCE ; POLYMORPHISMS ; BEHAVIOR ; RISK ; SUSCEPTIBILITY ; DISORDERS
收录类别	SCI
语种	英语
WOS记录号	WOS:000379495200004
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/20052]
专题	心理研究所_健康与遗传心理学研究室
作者单位	1.Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10065 USA 2.Tel Aviv Elias Sourasky Med Ctr, Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Tel Aviv, Israel 3.Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel 4.Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10065 USA 5.Chinese Acad Sci, Inst Psychol, Beijing, Peoples R China 6.Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA 7.VA New York Harbor Healthcare Syst, New York, NY 10016 USA 8.NYU, Sch Med, New York, NY 10016 USA 9.Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Las Vegas, NV 89169 USA
推荐引用方式 GB/T 7714	Levran, Orna,Randesi, Matthew,Peles, Einat,et al. African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction[J]. PHARMACOGENOMICS,2016,17(9):995-1003.
APA	Levran, Orna.,Randesi, Matthew.,Peles, Einat.,da Rosa, Joel Correa.,Ott, Jurg.,...&Kreek, Mary Jeanne.(2016).African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction.PHARMACOGENOMICS,17(9),995-1003.
MLA	Levran, Orna,et al."African-specific variability in the acetylcholine muscarinic receptor M4: association with cocaine and heroin addiction".PHARMACOGENOMICS 17.9(2016):995-1003.