Relationships between the Regulatory Systems of Quorum Sensing and Multidrug Resistance

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	Relationships between the Regulatory Systems of Quorum Sensing and Multidrug Resistance
	Xu, Gang-Ming
刊名	FRONTIERS IN MICROBIOLOGY
	2016-06-16
卷号	7
关键词	regulatory system quorum sensing multidrug resistance transcriptional regulator signal molecule
英文摘要	Cell cell communications, known as quorum sensing (QS) in bacteria, involve the signal molecules as chemical languages and the corresponding receptors as transcriptional regulators. In Gram-negative bacteria, orphan LuxR receptors recognize signals more than just acylhomoserine lactones, and modulate interspecies and interkingdom communications. Whereas, in the Gram-positive Streptomyces, pseudo gamma-butyrolactones (GBLs) receptors bind antibiotics other than GBL signals, and coordinate antibiotics biosynthesis. By interacting with structurally diverse molecules like antibiotics, the TetR family receptors regulate multidrug resistance (MDR) by controlling efflux pumps. Antibiotics at subinhibitory concentration may act as signal molecules; while QS signals also have antimicrobial activity at high concentration. Moreover, the QS and MDR systems may share the same exporters to transport molecules. Among these orphan LuxR, pseudo GBL receptors, and MDR regulators, although only with low sequence homology, they have some structure similarity and function correlation. Therefore, perhaps there might be evolutionary relationship and biological relevance between the regulatory systems of QS and MDR. Since the QS systems become new targets for antimicrobial strategy, it would expand our understanding about the evolutionary history of these regulatory systems.
收录类别	SCI
语种	英语
WOS记录号	WOS:000377853100001
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.qdio.ac.cn/handle/337002/130988]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Xu, Gang-Ming. Relationships between the Regulatory Systems of Quorum Sensing and Multidrug Resistance[J]. FRONTIERS IN MICROBIOLOGY,2016,7.
APA	Xu, Gang-Ming.(2016).Relationships between the Regulatory Systems of Quorum Sensing and Multidrug Resistance.FRONTIERS IN MICROBIOLOGY,7.
MLA	Xu, Gang-Ming."Relationships between the Regulatory Systems of Quorum Sensing and Multidrug Resistance".FRONTIERS IN MICROBIOLOGY 7(2016).