The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity

	The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity
	Jin, Weihua 1,3; Zhang, Wenjing1,2 ; Liang, Hongze 4; Zhang, Quanbin 1,3
刊名	MARINE DRUGS
	2016
卷号	14 期号:1
关键词	marine algae polysaccharides anti-complement activity structure-activity relationship
英文摘要	In this study, 33 different polysaccharides were prepared to investigate the structure-activity relationships between the polysaccharides, mainly from marine algae, and anti-complement activity in the classical pathway. Factors considered included extraction methods, fractionations, molecular weight, molar ratio of galactose to fucose, sulfate, uronic acid (UA) content, linkage, branching, and the type of monosaccharide. It was shown that the larger the molecular weights, the better the activities. The molar ratio of galactose (Gal) to fucose (Fuc) was a positive factor at a concentration lower than 10 mu g/mL, while it had no effect at a concentration more than 10 mu g/mL. In addition, sulfate was necessary; however, the sulfate content, the sulfate pattern, linkage and branching had no effect at a concentration of more than 10 mu g/mL. Moreover, the type of monosaccharide had no effect. Laminaran and UA fractions had no activity; however, they could reduce the activity by decreasing the effective concentration of the active composition when they were mixed with the active compositions. The effect of the extraction methods could not be determined. Finally, it was observed that sulfated galactofucan showed good anti-complement activity after separation.
收录类别	SCI
语种	英语
WOS记录号	WOS:000374586800003
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.qdio.ac.cn/handle/337002/131088]
专题	海洋研究所_海洋生物技术研发中心
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 4.Ningbo Univ, Sch Mat Sci & Chem Engn, Ningbo 315211, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Jin, Weihua,Zhang, Wenjing,Liang, Hongze,et al. The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity[J]. MARINE DRUGS,2016,14(1).
APA	Jin, Weihua,Zhang, Wenjing,Liang, Hongze,&Zhang, Quanbin.(2016).The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity.MARINE DRUGS,14(1).
MLA	Jin, Weihua,et al."The Structure-Activity Relationship between Marine Algae Polysaccharides and Anti-Complement Activity".MARINE DRUGS 14.1(2016).