Discovery of a F-19 MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振应用研究部

	Discovery of a F-19 MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells
	Shi, Qiuyan 1,2; Li, Yu 1,2; Bo, Shaowei 1,2; Li, Xiaofei 1,2; Zhao, Peng 3; Liu, Qi 1,2; Yang, Zhigang 1,2; Cong, Hengjiang 1,2; Deng, Hexiang 1,2; Chen, Mingnan 3
刊名	CHEMICAL COMMUNICATIONS
	2016
卷号	52 期号:29 页码:5136-5139
英文摘要	Salinomycin is a promising anti-cancer agent which selectively targets cancer stem cells. To improve its potency and selectivity, an analog library of salinomycin was generated by site-specific modification and CuAAc derivatization. Through a cytotoxicity analysis of the library, a fluorinated analog with high potency, selectivity, and F-19 MRI sensitivity was discovered as a novel theranostic agent.
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	ANTIBACTERIAL ACTIVITY ; ANTIPROLIFERATIVE ACTIVITY ; STEM-CELLS ; ESTERS ; AMIDES
收录类别	SCI
语种	英语
WOS记录号	WOS:000373629800012
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/9319]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China 2.Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430071, Peoples R China 3.Univ Utah, Sch Pharm, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84112 USA 4.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Subst, 345 Lingling Lu, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Shi, Qiuyan,Li, Yu,Bo, Shaowei,et al. Discovery of a F-19 MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells[J]. CHEMICAL COMMUNICATIONS,2016,52(29):5136-5139.
APA	Shi, Qiuyan.,Li, Yu.,Bo, Shaowei.,Li, Xiaofei.,Zhao, Peng.,...&Jiang, Zhong-Xing.(2016).Discovery of a F-19 MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells.CHEMICAL COMMUNICATIONS,52(29),5136-5139.
MLA	Shi, Qiuyan,et al."Discovery of a F-19 MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells".CHEMICAL COMMUNICATIONS 52.29(2016):5136-5139.