Highly enantioselective direct Michael addition of 1,3-dicarbonyl compounds to beta-fluoroalkyl-alpha-nitroalkenes | |
Zhao Y(赵燕)1; Wang XJ(王小进)1; Lin Y(林云)1; Cai CX(蔡晨新)1; Liu JT(刘金涛)1 | |
刊名 | Tetrahedron |
2014 | |
卷号 | 70期号:15页码:2523-2528 |
其他题名 | 1,3-二羰基化合物与β-氟烷基-α-硝基烯烃的高对映选择性Michael加成反应 |
通讯作者 | 刘金涛 |
英文摘要 | Cinchona alkaloid catalysts were used in the Michael addition reaction of 1,3-dicarbonyl compounds to beta-fluoroalkyl-alpha-nitroalkenes for the first time. The catalytic system performed well over a broad scope of substrates including beta-keto esters and 1,3-diketones with high diastereoselectivities and excellent enantioselectivities (up to 99% ee) under mild conditions. A wide range of useful fluorinated chiral building blocks was synthesized. (C) 2014 Elsevier Ltd. All rights reserved. |
学科主题 | 氟化学 |
收录类别 | SCI |
原文出处 | http://dx.doi.org/10.1016/j.tet.2014.02.062 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.sioc.ac.cn/handle/331003/38836] |
专题 | 上海有机化学研究所_中科院有机氟化学重点实验室 |
作者单位 | 1.中科院上海有机化学研究所 2.南京师范大学 |
推荐引用方式 GB/T 7714 | Zhao Y,Wang XJ,Lin Y,et al. Highly enantioselective direct Michael addition of 1,3-dicarbonyl compounds to beta-fluoroalkyl-alpha-nitroalkenes[J]. Tetrahedron,2014,70(15):2523-2528. |
APA | 赵燕,王小进,林云,蔡晨新,&刘金涛.(2014).Highly enantioselective direct Michael addition of 1,3-dicarbonyl compounds to beta-fluoroalkyl-alpha-nitroalkenes.Tetrahedron,70(15),2523-2528. |
MLA | 赵燕,et al."Highly enantioselective direct Michael addition of 1,3-dicarbonyl compounds to beta-fluoroalkyl-alpha-nitroalkenes".Tetrahedron 70.15(2014):2523-2528. |
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