Effect of Stereochemistry of Avermectin-Like 6,6Spiroketals on Biological Activities and Endogenous Biotransformations in Streptomyces avermectinius

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	Effect of Stereochemistry of Avermectin-Like 6,6Spiroketals on Biological Activities and Endogenous Biotransformations in Streptomyces avermectinius
	Sun P(孙鹏)1; Zhao QF(赵群飞)1; Zhang H(张华)1; Wu JQ(吴杰群)1; Liu W(刘文)1
刊名	ChemBioChem
	2014
卷号	15 期号:5 页码:660-664
其他题名	阿维菌素机构类似物中6,6-螺环的立体化学对生物活性及在除虫链霉菌中内源性生物转化的影响
通讯作者	刘文
英文摘要	Natural avermectins (AVEs) share a 6,6-spiroketal moiety with an exclusive R configuration at the C21 spirocyclic junction. Herein, we report the characterization of nine AVE-like spiroketals of two types (C21 S and R) in a mutant strain that lacks spirocyclase activity. Comparative analysis of their structures facilitated evaluation of the effect of stereochemistry on endogenous biotransformations and biological activities of the spiroketals.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1002/cbic.201300616
语种	英语
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/38937]
专题	上海有机化学研究所_生命有机化学国家重点实验室
作者单位	1.第二军医大学 2.中科院上海有机化学研究所 3.湖州生物制造创新中心
推荐引用方式 GB/T 7714	Sun P,Zhao QF,Zhang H,et al. Effect of Stereochemistry of Avermectin-Like 6,6Spiroketals on Biological Activities and Endogenous Biotransformations in Streptomyces avermectinius[J]. ChemBioChem,2014,15(5):660-664.
APA	孙鹏,赵群飞,张华,吴杰群,&刘文.(2014).Effect of Stereochemistry of Avermectin-Like 6,6Spiroketals on Biological Activities and Endogenous Biotransformations in Streptomyces avermectinius.ChemBioChem,15(5),660-664.
MLA	孙鹏,et al."Effect of Stereochemistry of Avermectin-Like 6,6Spiroketals on Biological Activities and Endogenous Biotransformations in Streptomyces avermectinius".ChemBioChem 15.5(2014):660-664.