CuBr-Promoted Tandem Cyclization/Trifluoromethylation of 2-Alkynylanilines: Efficient Synthesis of 3-Trifluoromethylindoles

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	CuBr-Promoted Tandem Cyclization/Trifluoromethylation of 2-Alkynylanilines: Efficient Synthesis of 3-Trifluoromethylindoles
	Ge GC(葛广存); Huang XJ(黄小军); Ding CH(丁昌华); LI HAO; WAN SHILI; Hou XL(侯雪龙)
刊名	Chin. J. Chem.
	2014
卷号	32 期号:8 页码:727-733
其他题名	CuBr促进的邻炔苯胺串联环化三氟甲基化反应: 高效合成3-三氟甲基吲哚
通讯作者	侯雪龙
英文摘要	A new efficient strategy for the synthesis of 3-trifluoromethyl-indoles was developed through tandem cyclization/trifluoromethylation of 2-alkynylanilines and Umemoto's reagent under effect of CuBr. The reaction features the use of cheap copper salt, mild reaction conditions and high yield of products. The preliminary mechanism study indicates the solvent dimethylacetamide acts as the role of dealkylation.
学科主题	金属有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1002/cjoc.201400298
语种	英语
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/39108]
专题	上海有机化学研究所_金属有机化学国家重点实验室
作者单位	中科院上海有机化学研究所
推荐引用方式 GB/T 7714	Ge GC,Huang XJ,Ding CH,et al. CuBr-Promoted Tandem Cyclization/Trifluoromethylation of 2-Alkynylanilines: Efficient Synthesis of 3-Trifluoromethylindoles[J]. Chin. J. Chem.,2014,32(8):727-733.
APA	葛广存,黄小军,丁昌华,LI HAO,WAN SHILI,&侯雪龙.(2014).CuBr-Promoted Tandem Cyclization/Trifluoromethylation of 2-Alkynylanilines: Efficient Synthesis of 3-Trifluoromethylindoles.Chin. J. Chem.,32(8),727-733.
MLA	葛广存,et al."CuBr-Promoted Tandem Cyclization/Trifluoromethylation of 2-Alkynylanilines: Efficient Synthesis of 3-Trifluoromethylindoles".Chin. J. Chem. 32.8(2014):727-733.