Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates

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	Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates
	ZHONG SABILLA 1; NIEGER MARTIN 1; BIHLMEIER ANGELA 1; Shi M(施敏)1; BRAESE STEFAN 1
刊名	Org. Biomol. Chem.
	2014
卷号	12 期号:20 页码:3265-3270
其他题名	不对称有机催化合成双吲哚哌啶羧酸酯
通讯作者	施敏 ; BRAESE STEFAN
英文摘要	We developed an asymmetric organocatalytic synthesis of 4,6-bis(1H-indole-3-yl)-piperidine-2-carboxylates using 10 mol% of a chiral phosphoric acid. The products, which are novel bisindole-piperidine-amino acid hybrids, can be obtained in one step from 3-vinyl indoles with imino esters in dichloromethane at room temperature after 1 h of reaction time. A variety of these compounds could be synthesized in up to 70% yield and 99% ee, and they were experimentally and computationally analyzed regarding their relative and absolute stereochemistry.
学科主题	金属有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1039/c4ob00234b
语种	英语
内容类型	期刊论文
源URL	[http://ir.sioc.ac.cn/handle/331003/39056]
专题	上海有机化学研究所_金属有机化学国家重点实验室
作者单位	1.中科院上海有机化学研究所 2.德国KIT有机化学研究所 3.芬兰赫尔辛基大学 4.德国KIT物理化学研究所
推荐引用方式 GB/T 7714	ZHONG SABILLA,NIEGER MARTIN,BIHLMEIER ANGELA,et al. Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates[J]. Org. Biomol. Chem.,2014,12(20):3265-3270.
APA	ZHONG SABILLA,NIEGER MARTIN,BIHLMEIER ANGELA,施敏,&BRAESE STEFAN.(2014).Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates.Org. Biomol. Chem.,12(20),3265-3270.
MLA	ZHONG SABILLA,et al."Asymmetric organocatalytic synthesis of 4,6-bis-(1H-indole-3-yl)-piperidine-2 carboxylates".Org. Biomol. Chem. 12.20(2014):3265-3270.