Reinforcement of injectable calcium phosphate cement by gelatinized starches

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	Reinforcement of injectable calcium phosphate cement by gelatinized starches
	Liu HL; Guan Y; Wei DL; Gao CX; Yang HL; Yang L
刊名	JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
	2016
通讯作者邮箱	leiy@suda.edu.cn
卷号	104 期号:3 页码:615-625
关键词	calcium phosphates composite mechanical properties starches injectable
ISSN号	1552-4973
通讯作者	Yang, L (reprint author), Soochow Univ, Affiliated Hosp 1, Inst Orthopaed, Dept Orthopaed, Suzhou 215006, Jiangsu, Peoples R China. ; Yang, L (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.
产权排序	[Liu, Huiling; Wei, Donglei; Gao, Chunxia; Yang, Huilin; Yang, Lei] Soochow Univ, Affiliated Hosp 1, Inst Orthopaed, Dept Orthopaed, Suzhou 215006, Jiangsu, Peoples R China; [Guan, Ying] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Jiangsu, Peoples R China; [Yang, Lei] Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China
中文摘要	Current injectable calcium phosphate bone cements (CPC) encounter the problems of low strength, high brittleness, and low cohesion in aqueous environment, which greatly hinder their clinical applications for loading-bearing bone substitution and minimally invasive orthopedic surgeries. Here, a strategy of using gelatinized starches to reinforce injectable CPC was investigated. Four types of starches, namely corn starch, crosslinked starch, cationic starch, and Ca-modified starch, were studied for their influence on CPC mechanical properties, injectability, setting times, anticollapsibility, and cytocompatibility. Gelatinized starch significantly improved compressive strength and modulus as well as strain energy density of CPC to different extents. Specifically, both corn starch and Ca-modified starch revealed sixfold and more than twofold increases in the compressive strength and modulus of CPC, respectively. The addition of gelatinized starches with proper contents increased the injectability and anticollapsibility of CPC. In addition, osteoblast proliferation tests on leaching solution of modified cements showed that gelatinized starches had no adverse effect on cell proliferation, and all cement samples resulted in better osteoblast proliferation compared to phosphate-buffered solution control. The mechanisms behind the reinforcing effect of different starches were preliminarily studied. Two possible mechanisms, reinforcement by the second phase of gelatinized starch and strong interlocking of apatite crystals, were proposed based on the results of starch zeta potential and viscosity, cement microstructure, and resultant mechanical properties. In conclusion, incorporating gelatinized starches could be an effective, facile, and bio-friendly strategy to reinforce injectable CPC and improve its mechanical stability, and thus, should be further studied and developed. (c) 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 615-625, 2016.
分类号	二类
类目[WOS]	Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]	Engineering ; Materials Science
关键词[WOS]	calcium phosphates ; composite ; mechanical properties ; starches ; injectable
收录类别	SCI
原文出处	http://dx.doi.org/10.1002/jbm.b.33434
语种	英语
WOS记录号	WOS:000372297100021
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/59543]
专题	力学研究所_非线性力学国家重点实验室
推荐引用方式 GB/T 7714	Liu HL,Guan Y,Wei DL,et al. Reinforcement of injectable calcium phosphate cement by gelatinized starches[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,2016,104(3):615-625.
APA	Liu HL,Guan Y,Wei DL,Gao CX,Yang HL,&Yang L.(2016).Reinforcement of injectable calcium phosphate cement by gelatinized starches.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,104(3),615-625.
MLA	Liu HL,et al."Reinforcement of injectable calcium phosphate cement by gelatinized starches".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 104.3(2016):615-625.