GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced Conditioned Place Preference in Rats

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	GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced Conditioned Place Preference in Rats
	Lin, Xiao-Jing 1,2,4; Zhang, Jian-Jun1,2,3 ; Yu, Long-Chuan 1,2
刊名	NEUROSCIENCE BULLETIN
	2016-04-01
卷号	32 期号:2 页码:177-182
关键词	GluR2-3Y AMPA receptors Morphine Conditioned place preference Acquisition of mCPP Reinstatement of mCPP
ISSN号	1673-7067
英文摘要	Accumulating evidence indicates that alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs) are involved in the relapse to abused drugs. However, the role of AMPARs containing the GluR2 subunit in opiate addiction is still unclear. GluR2-3Y, an interfering peptide, prevents the endocytosis of AMPARs containing the GluR2 subunit. In this study, we explored the effect of intravenous injection of GluR2-3Y on the acquisition, expression, and reinstatement of morphine-induced conditioned place preference (mCPP) in rats. We found that infusion of GluR2-3Y (1.5 nmol/g) one hour before morphine during the conditioning phase inhibited the acquisition of mCPP, while an identical injection one hour before the post-conditioning test had no influence on the expression of mCPP. Injection of GluR2-3Y (1.5 nmol/g) after mCPP extinction blocked the morphine-induced reinstatement of mCPP. Our results strongly support the hypothesis that inhibition of AMPAR endocytosis provides a new target for the treatment of opiate addiction.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	AMPA RECEPTOR ENDOCYTOSIS ; VENTRAL TEGMENTAL AREA ; LONG-TERM DEPRESSION ; BEHAVIORAL SENSITIZATION ; NUCLEUS-ACCUMBENS ; PREFRONTAL CORTEX ; EXPRESSION ; EXTINCTION ; ANTAGONIST ; LY293558
收录类别	SCI
语种	英语
WOS记录号	WOS:000373642800007
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/19963]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Peking Univ, Coll Life Sci, Neurobiol Lab, Beijing 100871, Peoples R China 2.Peking Univ, Coll Life Sci, Natl Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 4.Natl Inst Biol Sci, Beijing 102206, Peoples R China
推荐引用方式 GB/T 7714	Lin, Xiao-Jing,Zhang, Jian-Jun,Yu, Long-Chuan. GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced Conditioned Place Preference in Rats[J]. NEUROSCIENCE BULLETIN,2016,32(2):177-182.
APA	Lin, Xiao-Jing,Zhang, Jian-Jun,&Yu, Long-Chuan.(2016).GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced Conditioned Place Preference in Rats.NEUROSCIENCE BULLETIN,32(2),177-182.
MLA	Lin, Xiao-Jing,et al."GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced Conditioned Place Preference in Rats".NEUROSCIENCE BULLETIN 32.2(2016):177-182.