Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives

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	Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives
	Chan, Raymond C. K.1 ; Huang, Jia 1; Zhao, Qing 2,3; Wang, Ya1 ; Lai, Yun-yao 4; Hong, Nan 4; Shum, David H. K.2,3,5,6; Cheung, Eric F. C.7; Yu, Xin 8,9,10; Dazzan, Paola 11,12
刊名	NEUROIMAGE-CLINICAL
	2015
卷号	9 期号:0 页码:411-417
关键词	Neurological soft sign First episode schizophrenia First degree relatives Endophenotype
ISSN号	2213-1582
英文摘要	Neurological soft signs have been considered one of the promising neurological endophenotypes for schizophrenia. However, most previous studies have employed clinical rating data only. The present study aimed to examine the neurobiological basis of one of the typical motor coordination signs, the Fist-Edge-Palm (FEP) task, in patients with first-episode schizophrenia and their non-psychotic first degree relatives. Thirteen patients with first-episode schizophrenia, 14 non-psychotic first-degree relatives and 14 healthy controls were recruited. All of themwere instructed to performthe FEP task in a 3 T GEMachine. Psychophysiological interaction (PPI) analysiswas used to evaluate the functional connectivity between the sensorimotor cortex and frontal regionswhen participants performed the FEP task compared to simplemotor tasks. In the contrast of palm-tapping (PT) vs. rest, activation of the left frontal-parietal region was lowest in the schizophrenia group, intermediate in the relative group and highest in the healthy control group. In the contrast of FEP vs. PT, patients with schizophrenia did not show areas of significant activation, while relatives and healthy controls showed significant activation of the left middle frontal gyrus. Moreover, with the increase in task complexity, significant functional connectivity was observed between the sensorimotor cortex and the right frontal gyrus in healthy controls but not in patients with first episode schizophrenia. These findings suggest that activity of the left frontal-parietal and frontal regions may be neurofunctional correlates of neurological soft signs, which in turn may be a potential endophenotype of schizophrenia. Moreover, the right frontal gyrus may play a specific role in the execution of the FEP task in schizophrenia spectrum disorders. (C) 2015 The Authors. Published by Elsevier Inc.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neuroimaging
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	NEUROLOGICAL SOFT SIGNS ; SENSORIMOTOR CORTEX ; PSYCHOTIC SYMPTOMS ; BRAIN ACTIVATION ; WORKING-MEMORY ; HIGH-RISK ; MOTOR ; METAANALYSIS ; MORPHOLOGY ; SIBLINGS
收录类别	SCI ; SSCI
语种	英语
WOS记录号	WOS:000373188400044
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/19962]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Griffith Univ, Sch Appl Psychol, Brisbane, Qld 4111, Australia 3.Griffith Univ, Behav Basis Hlth Program, Griffith Hlth Inst, Brisbane, Qld 4111, Australia 4.Peking Univ, Peoples Hosp, Radiol Dept, Beijing, Peoples R China 5.Griffith Univ, Menzies Hlth Inst Queensland, Gold Coast, Australia 6.Griffith Univ, Sch Appl Psychol, Gold Coast, Australia 7.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 8.Peking Univ, Hosp 6, Beijing 100871, Peoples R China 9.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China 10.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Chan, Raymond C. K.,Huang, Jia,Zhao, Qing,et al. Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives[J]. NEUROIMAGE-CLINICAL,2015,9(0):411-417.
APA	Chan, Raymond C. K..,Huang, Jia.,Zhao, Qing.,Wang, Ya.,Lai, Yun-yao.,...&Dazzan, Paola.(2015).Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives.NEUROIMAGE-CLINICAL,9(0),411-417.
MLA	Chan, Raymond C. K.,et al."Prefrontal cortex connectivity dysfunction in performing the Fist-Edge-Palm task in patients with first-episode schizophrenia and non-psychotic first-degree relatives".NEUROIMAGE-CLINICAL 9.0(2015):411-417.