The effect of Gd@C-82(OH)(22) nanoparticles on the release of Th1/Th2 cytokines and induction of TNF-alpha mediated cellular immunity

	The effect of Gd@C-82(OH)(22) nanoparticles on the release of Th1/Th2 cytokines and induction of TNF-alpha mediated cellular immunity
	Liu, Y; Jiao F(焦芳); Li W(李炜); Zhou GQ(周国强); Sun BY(孙宝云); Xing GM(邢更妹); Dong JQ(董金泉); Zhao YL(赵宇亮); Chai ZF(柴之芳); Chen CY(陈春英)
刊名	BIOMATERIALS
	2009
卷号	30 期号:23-24 页码:3934-3945
关键词	Nanoparticle Cytotoxicity Immune response Macrophage
通讯作者	[Liu, Ying ; Qiu, Yang ; Lao, Fang ; Zhao, Yuliang ; Chen, Chunying] CAS, Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China ; [Jiao, Fang ; Li, Wei ; Zhou, Guoqiang ; Sun, Baoyun ; Xing, Genmei ; Dong, Jinquan ; Zhao, Yuliang ; Chai, Zhifang ; Chen, Chunying] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China ; [Jiao, Fang ; Li, Wei ; Zhou, Guoqiang ; Sun, Baoyun ; Xing, Genmei ; Dong, Jinquan ; Zhao, Yuliang ; Chai, Zhifang ; Chen, Chunying] Chinese Acad Sci, Key Lab Nucl Tech, Inst High Energy Phys, Beijing 100049, Peoples R China
英文摘要	It is known that down-regulation of the immune response may be associated with the progenesis, development and prognosis of cancer or infectious diseases. Up-regulating the immune response in vivo is therefore a desirable strategy for clinical treatment. Here we report that poly-hydroxylated metallofullerenol (Gd@C-82(OH)(22)) has biomedical functions useful in anticancer therapy arising from immunomodulatory effects observed both in vivo and in vitro. We found that metallofullerenol can inhibit the growth of tumors, and shows specific immunomodulatory effects on T cells and macrophages. These effects include polarizing the cytokine balance towards Th1 (T-helper cell type 1) cytokines, decreasing the production of Th2 cytokines (IL-4, IL-5 and IL-6), and increasing the production of Th1 cytokines (IL-2, IFN-gamma and TNF-alpha) in the serum samples. Immune-system regulation by this nanomaterial showed dose-dependent behavior: at a low concentration, Gd@C-82(OH)(22) nanoparticles slightly affected the activity of immune cells in vitro, while at a high concentration, they markedly enhanced immune responses and stimulated immune cells to release more cytokines, helping eliminate abnormal cells. Gd@C-82(OH)(22) nanoparticles stimulated T cells and macrophages to release significantly greater quantities of TNF-alpha, which plays a key role in cellular immune processes. Gd@C-82(OH)(22) nanoparticles are more effective in inhibiting tumor growth in mice than some clinical anticancer drugs but have negligible side effects. The underlying mechanism for high anticancer activity may be attributed to the fact that this water-soluble nanomaterial effectively triggers the host immune system to scavenge tumor cells. (C) 2009 Elsevier Ltd. All rights reserved.
学科主题	Engineering; Materials Science
类目[WOS]	Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]	Engineering ; Materials Science
原文出处	SCI
语种	英语
WOS记录号	WOS:000267469300014
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/239953]
专题	高能物理研究所_院士高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Liu, Y,Jiao F,Li W,et al. The effect of Gd@C-82(OH)(22) nanoparticles on the release of Th1/Th2 cytokines and induction of TNF-alpha mediated cellular immunity[J]. BIOMATERIALS,2009,30(23-24):3934-3945.
APA	Liu, Y.,焦芳.,李炜.,周国强.,孙宝云.,...&Chen, CY.(2009).The effect of Gd@C-82(OH)(22) nanoparticles on the release of Th1/Th2 cytokines and induction of TNF-alpha mediated cellular immunity.BIOMATERIALS,30(23-24),3934-3945.
MLA	Liu, Y,et al."The effect of Gd@C-82(OH)(22) nanoparticles on the release of Th1/Th2 cytokines and induction of TNF-alpha mediated cellular immunity".BIOMATERIALS 30.23-24(2009):3934-3945.