Biosafety assessment of Gd@C-82(OH)(22) nanoparticles on Caenorhabditis elegans

	Biosafety assessment of Gd@C-82(OH)(22) nanoparticles on Caenorhabditis elegans
	Zhang, WD; Sun BY(孙宝云); Zhao YL(赵宇亮); Sun, BY; Zhang, LZ; Zhao, BL; Nie, GJ; Zhao, YL
刊名	NANOSCALE
	2011
卷号	3 期号:6 页码:2636-2641
通讯作者	[Zhang, Wendi ; Nie, Guangjun ; Zhao, Yuliang] Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China ; [Sun, Baoyun ; Zhao, Yuliang] Chinese Acad Sci, Inst High Energy Phys, Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Zhang, Longze ; Zhao, Baolu] Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China
英文摘要	Gd@C-82(OH)(22), a water-soluble endohedral metallofullerene derivative, has been proven to possess significant antineoplastic activity in mice. Toxicity studies of the nanoparticle have shown some evidence of low or non toxicity in mice and cell models. Here we employed Caenorhabditis elegans (C. elegans) as a model organism to further evaluate the short-and long-term toxicity of Gd@C-82(OH)(22) and possible behavior changes under normal and stress culture conditions. With treatment of Gd@C-82(OH)(22) at 0.01, 0.1, 1.0 and 10 mg ml(-1) within one generation (short-term), C. elegans showed no significant decrease in longevity or thermotolerance compared to the controls. Furthermore, when Gd@C-82(OH)(22) treatment was extended up to six generations (long-term), nontoxic effects to the nematodes were found. In addition, data from body length measurement, feeding rate and egg-laying assays with short-term treatment demonstrated that the nanoparticles have no significant impact on the individual growth, feeding behavior and reproductive ability, respectively. In summary, this work has shown that Gd@C-82(OH)(22) is tolerated well by worms and it has no apparent toxic effects on longevity, stress resistance, growth and behaviors that were observed in both adult and young worms. Our work lays the foundations for further developments of this anti-neoplastic agent for clinical applications.
学科主题	Chemistry; Science & Technology - Other Topics; Materials Science; Physics
类目[WOS]	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
原文出处	SCI
语种	英语
WOS记录号	WOS:000291663500038
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/239798]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Zhang, WD,Sun BY,Zhao YL,et al. Biosafety assessment of Gd@C-82(OH)(22) nanoparticles on Caenorhabditis elegans[J]. NANOSCALE,2011,3(6):2636-2641.
APA	Zhang, WD.,孙宝云.,赵宇亮.,Sun, BY.,Zhang, LZ.,...&Zhao, YL.(2011).Biosafety assessment of Gd@C-82(OH)(22) nanoparticles on Caenorhabditis elegans.NANOSCALE,3(6),2636-2641.
MLA	Zhang, WD,et al."Biosafety assessment of Gd@C-82(OH)(22) nanoparticles on Caenorhabditis elegans".NANOSCALE 3.6(2011):2636-2641.