Adolescent escitalopram administration modifies neurochemical alterations in the hippocampus of maternally separated rats

	Adolescent escitalopram administration modifies neurochemical alterations in the hippocampus of maternally separated rats
	Hui, JJ; Zhang, ZJ; Liu, SS; Xi, GJ; Zhang, XR; Teng, GJ; Chan, KC; Wu, EX; Nie, BB; Shan, BC
刊名	EUROPEAN NEUROPSYCHOPHARMACOLOGY
	2010
卷号	20 期号:12 页码:875-883
关键词	Hippocampus Maternal separation Escitalopram Magnetic resonance imaging Proton magnetic resonance spectroscopy Rat
通讯作者	[Hui, Jiaojie ; Zhang, Zhijun ; Liu, Shanshan ; Xi, Guangjun ; Zhang, Xiangrong] Southeast Univ, Dept Neurol, Affiliated ZhongDa Hosp, Nanjing, Jiangsu, Peoples R China ; [Hui, Jiaojie ; Zhang, Zhijun ; Liu, Shanshan ; Xi, Guangjun ; Zhang, Xiangrong ; Teng, GaoJun] Southeast Univ, Sch Clin Med, Nanjing, Jiangsu, Peoples R China ; [Teng, GaoJun] Southeast Univ, Inst Mol Imaging, Nanjing, Jiangsu, Peoples R China ; [Chan, Kevin C. ; Wu, Ed X.] Univ Hong Kong, Lab Biomed Imaging & Signal Proc, Pokfulam, Hong Kong, Peoples R China ; [Chan, Kevin C. ; Wu, Ed X.] Univ Hong Kong, Dept Elect & Elect Engn, Pokfulam, Hong Kong, Peoples R China ; [Nie, Binbin] Zhengzhou Univ, Phys Sci & Technol Coll, Zhengzhou, Henan, Peoples R China ; [Nie, Binbin ; Shan, Baoci] Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing, Peoples R China ; [Li, Lingjiang] Cent S Univ, Xiangya Hosp 2, Mental Hlth Inst, Changsha, Hunan, Peoples R China ; [Reynolds, Gavin P.] Queens Univ Belfast, Dept Psychiat, Belfast BT9 7BL, Antrim, North Ireland
英文摘要	Early life stress is a potential precursor of eventual neuropsychiatric diseases and may result in altered neurodevelopment and function of the hippocampus, which thus provides a site at which potential interventions to modify the effects of early life stress may act. In this study, Sprague Dawley rat pups comprising male and female animals underwent maternal separation (MS) for 180 min from postnatal days (PND) 2 to 14, or were left with their dams. They subsequently received daily administration of saline (0.9%), escitalopram (10 mg/kg), or no treatment during adolescence (PND 43-60). All adult animals underwent brain magnetic resonance imaging (MRI) and bilateral hippocampal proton magnetic resonance spectroscopy ((1)H-MRS). Neither MS nor escitalopram treatment had a significant effect on hippocampal volume. Adult rats that experienced MS displayed significantly increased choline-containing compounds (Cho) and decreased N-acetylaspartate (NAA), glutamate (Glu) and Myo-inositol (MI) relative to the stable neurometabolite creatine (Cr) in hippocampus. Administration of escitalopram during adolescence could modify the alterations of NAA/Cr, Glu/Cr and MI/Cr. The effects of MS on hippocampal neurochemistry were most significant in the right hippocampus. These results indicate that MS in rats has long-term consequences on hippocampal neurochemistry reflective of neural density/functional integrity, especially on the right hippocampus, and adolescent administration with escitalopram can at least partially ameliorate these neurochemical alterations. Furthermore, these metabolite changes seem to be more sensitive indicators of the results from early life stress than volume changes. (C) 2010 Elsevier B.V. and ECNP. All rights reserved
学科主题	Neurosciences & Neurology; Pharmacology & Pharmacy; Psychiatry
类目[WOS]	Clinical Neurology ; Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]	Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
原文出处	SCI
语种	英语
WOS记录号	WOS:000284569600006
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/238658]
专题	高能物理研究所_多学科研究中心高能物理研究所_核技术应用研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Hui, JJ,Zhang, ZJ,Liu, SS,et al. Adolescent escitalopram administration modifies neurochemical alterations in the hippocampus of maternally separated rats[J]. EUROPEAN NEUROPSYCHOPHARMACOLOGY,2010,20(12):875-883.
APA	Hui, JJ.,Zhang, ZJ.,Liu, SS.,Xi, GJ.,Zhang, XR.,...&单保慈.(2010).Adolescent escitalopram administration modifies neurochemical alterations in the hippocampus of maternally separated rats.EUROPEAN NEUROPSYCHOPHARMACOLOGY,20(12),875-883.
MLA	Hui, JJ,et al."Adolescent escitalopram administration modifies neurochemical alterations in the hippocampus of maternally separated rats".EUROPEAN NEUROPSYCHOPHARMACOLOGY 20.12(2010):875-883.