The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials

	The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials
	Yin, JJ; Lao, F; Fu, PP; Wamer, WG; Zhao, YL; Wang, PC; Qiu, Y; Sun, BY; Xing, GM; Dong, JQ
刊名	BIOMATERIALS
	2009
卷号	30 期号:4 页码:611-621
关键词	Gadolinium endohedral metallofullerenol Fullerenol Carboxyfullerene Scavenging activity Cytoprotection Reactive oxygen species
通讯作者	[Lao, Fang ; Zhao, Yuliang ; Qiu, Yang ; Liang, Xing-Jie ; Chen, Chunying] Natl Ctr Nanosci & Technol China, Div Nanomed & Nanobiol, Beijing 100190, Peoples R China ; [Yin, Jun-Jie ; Wamer, Wayne G.] US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD 20740 USA ; [Zhao, Yuliang ; Sun, Baoyun ; Xing, Gengmei ; Dong, Jinquan ; Chen, Chunying] Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China ; [Fu, Peter P.] US FDA, Natl Ctr Toxicol Res, Div Biochem Toxicol, Jefferson, AR 72079 USA ; [Wang, Paul C.] Howard Univ, Dept Radiol, Lab Mol Imaging, Washington, DC 20060 USA
英文摘要	We demonstrated that three different types of water-soluble fullerenes materials can intercept all of the major physiologically relevant ROS. C(60)(C(COOH)(2))(2), C(60)(OH)(22), and Gd@C(82)(OH)(22) can protect cells against H(2)O(2)-induced oxidative damage, stabilize the mitochondrial membrane potential and reduce intracellular ROS production with the following relative potencies: Gd@C(82)(OH)(22)>= C(60)(OH)(22)> C(60)(C(COOH)(2))(2). Consistent with their cytoprotective abilities, these derivatives can scavenge the stable 2,2-diplienyl-1-picryhydrazl radical (DPPH), and the reactive oxygen species (ROS) superoxide radical anion (O(2)(center dot-)). singlet oxygen, and hydroxyl radical (HO(center dot)), and can also efficiently inhibit lipid peroxidation in vitro. The observed differences in free radical-scavenging capabilities Support the hypothesis that both chemical Properties, such as Surface chemistry induced differences in electron affinity, and physical properties, such as degree of aggregation, influence the biological and biomedical activities of functionalized fullerenes. This represents the first report that different types of fullerene derivatives can scavenge all physiologically relevant ROS. The role of oxidative stress and damage in the etiology and Progression of many diseases suggests that these fullerene derivatives may be valuable in vivo cytoprotective and therapeutic agents. (C) 2008 Elsevier Ltd. All rights reserved.
学科主题	Engineering; Materials Science
类目[WOS]	Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]	Engineering ; Materials Science
原文出处	SCI
语种	英语
WOS记录号	WOS:000262065500023
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/238103]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Yin, JJ,Lao, F,Fu, PP,et al. The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials[J]. BIOMATERIALS,2009,30(4):611-621.
APA	Yin, JJ.,Lao, F.,Fu, PP.,Wamer, WG.,Zhao, YL.,...&陈春英.(2009).The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials.BIOMATERIALS,30(4),611-621.
MLA	Yin, JJ,et al."The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials".BIOMATERIALS 30.4(2009):611-621.