Delayed changes in T-1-weighted signal intensity in a rat model of 15-minute transient focal ischemia studied by magnetic resonance imaging/spectroscopy and synchrotron radiation X-ray fluorescence

	Delayed changes in T-1-weighted signal intensity in a rat model of 15-minute transient focal ischemia studied by magnetic resonance imaging/spectroscopy and synchrotron radiation X-ray fluorescence
	Wang, XX; Qian, JC; He, R; Wei, L; Liu, NQ; Zhang, ZY; Huang, YY; Lei, H; Liu NQ(刘年庆); Zhang ZY(张智勇)
刊名	MAGNETIC RESONANCE IN MEDICINE
	2006
卷号	56 期号:3 页码:474-480
关键词	magnetic resonance synchrotron radiation X-ray fluorescence brain transient focal ischemia rat
通讯作者	Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China ; Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China ; Chinese Acad Sci, Inst High Energy Phys, Lab Nucl Analyt Techn, Beijing 100080, Peoples R China ; Chinese Acad Sci, Inst High Energy Phys, Beijing Synchrotron Radiat Lab, Beijing 100080, Peoples R China
英文摘要	Previous studies have found that rats subjected to 15-min transient middle cerebral artery occlusion (MCAO) show neurodegeneration in the dorsolateral striatum only, and the resulting striatal lesion is associated with increased T-1-weighted (T1W) signal intensity (SI) and decreased T-2-weighted (T2W SI at 2-8 weeks after the initial ischemia. It has been shown that the delayed increase in T1W SI in the ischemic region is associated with deposition of paramagnetic manganese ions. However, it has been suggested that other mechanisms, such as tissue calcification and lipid accumulation, also contribute to the relaxation time changes. To clarify this issue, we measured changes in relaxation times, lipid accumulation, and elemental distributions in the brain of rats subjected to 15-min MCAO using MRI, in vivo H-1 MR spectroscopy (MRS), and synchrotron radiation X-ray fluorescence (SRXRF). The results show that a delayed (2 weeks after ischemia) increase in T1W SI in the ischemic striatum is associated with significant increases in manganese, calcium, and iron, but without evident accumulation of MRS-visible lipids or hydroxyapatite precipitation. It was also found that 15-min MCAO results in acutely reduced N-acetylaspartate (NAA)/creatine (Cr) ratio in the ipsilateral striatum, which recovers to the control level at 2 weeks after ischemia.
学科主题	Radiology, Nuclear Medicine & Medical Imaging
类目[WOS]	Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]	Radiology, Nuclear Medicine & Medical Imaging
原文出处	SCI
语种	英语
WOS记录号	WOS:000240245600002
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/237632]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Wang, XX,Qian, JC,He, R,et al. Delayed changes in T-1-weighted signal intensity in a rat model of 15-minute transient focal ischemia studied by magnetic resonance imaging/spectroscopy and synchrotron radiation X-ray fluorescence[J]. MAGNETIC RESONANCE IN MEDICINE,2006,56(3):474-480.
APA	Wang, XX.,Qian, JC.,He, R.,Wei, L.,Liu, NQ.,...&张智勇.(2006).Delayed changes in T-1-weighted signal intensity in a rat model of 15-minute transient focal ischemia studied by magnetic resonance imaging/spectroscopy and synchrotron radiation X-ray fluorescence.MAGNETIC RESONANCE IN MEDICINE,56(3),474-480.
MLA	Wang, XX,et al."Delayed changes in T-1-weighted signal intensity in a rat model of 15-minute transient focal ischemia studied by magnetic resonance imaging/spectroscopy and synchrotron radiation X-ray fluorescence".MAGNETIC RESONANCE IN MEDICINE 56.3(2006):474-480.