A micro-tomography method based on X-ray diffraction enhanced imaging for the visualization of micro-organs and soft tissues

	A micro-tomography method based on X-ray diffraction enhanced imaging for the visualization of micro-organs and soft tissues
	Gao, X; Luo, SQ; Yin, HX; Liu, B; Xu, ML; Yuan, QX; Gao, XL; Zhu, PP; Yuan QX(袁清习); Zhu PP(朱佩平)
刊名	COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
	2006
卷号	30 期号:6-7 页码:339-347
关键词	micro-tomography diffraction enhanced imaging ohase contrast imaging high resolution cochlea of guinea pig liver tissues
通讯作者	Capital Univ Med Sci, Med Image Lab, Coll Biomed Engn, Beijing 100069, Peoples R China ; Capital Univ Med Sci, Dept Anat, Beijing 100069, Peoples R China ; Chinese Acad Sci, Natl Lab Pattern Recognit, Beijing, Peoples R China ; Chinese Acad Sci, Inst High Energy Phys, Beijing, Peoples R China ; Beijing Informat Technol Inst, Beijing, Peoples R China
英文摘要	Diffraction enhanced imaging (DEI) is one of the phase contrast imaging methods using the monochromatic X-ray from synchrotron, which provides information on the out-of-plane angular deviation of X-ray. DO allows the investigation of micro-structures inside weakly absorbing samples at high spatial resolution without serious radiation exposure. Tomographic techniques can be applied readily to phase contrast images. The combination of DEI and tomography allows for a reconstruction of refractive index gradient distribution inside weakly absorbing samples with micrometer resolution, particularly suited for the 3D observation of micro-organisms and tissues. The existing phase contrast tomography methods based on DEI use phase contrast images as projections, such images contain not only the phase information, but also the absorption information. A novel method (DEI in the tomography mode) was developed to greatly increase the proportion of refraction information in phase contrast images by computing the difference between the two sets of images acquired at different angles of the rocking curve to adopt the projections with a complete set (2 pi) for reconstruction. The reconstructed images of cochlea of a guinea pig showed the spatial structures and the micro-features inside the samples. The new method reveals higher spatial resolution compared to the conventional phase contrast tomography methods and is more suitable to the investigation of micro- structures of micro-organisms and tissue materials. (c) 2006 Elsevier Ltd. All rights reserved.
学科主题	Radiology, Nuclear Medicine & Medical Imaging
类目[WOS]	Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]	Radiology, Nuclear Medicine & Medical Imaging
原文出处	SCI
语种	英语
WOS记录号	WOS:000242759900003
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/237054]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Gao, X,Luo, SQ,Yin, HX,et al. A micro-tomography method based on X-ray diffraction enhanced imaging for the visualization of micro-organs and soft tissues[J]. COMPUTERIZED MEDICAL IMAGING AND GRAPHICS,2006,30(6-7):339-347.
APA	Gao, X.,Luo, SQ.,Yin, HX.,Liu, B.,Xu, ML.,...&朱佩平.(2006).A micro-tomography method based on X-ray diffraction enhanced imaging for the visualization of micro-organs and soft tissues.COMPUTERIZED MEDICAL IMAGING AND GRAPHICS,30(6-7),339-347.
MLA	Gao, X,et al."A micro-tomography method based on X-ray diffraction enhanced imaging for the visualization of micro-organs and soft tissues".COMPUTERIZED MEDICAL IMAGING AND GRAPHICS 30.6-7(2006):339-347.