Functional Reorganizations of Brain Network in Prelingually Deaf Adolescents

CORC > 自动化研究所 > 中国科学院自动化研究所 > 复杂系统管理与控制国家重点实验室 > 影像分析与机器视觉团队

	Functional Reorganizations of Brain Network in Prelingually Deaf Adolescents
	Li, Wenjing 1,2,3; Li, Jianhong 4; Wang, Jieqiong2 ; Zhou, Peng2 ; Wang, Zhenchang 5; Xian, Junfang 4; He, Huiguang2
刊名	NEURAL PLASTICITY
	2016
英文摘要	Previous neuroimaging studies suggested structural or functional brain reorganizations occurred in prelingually deaf subjects. However, little is known about the reorganizations of brain network architectures in prelingually deaf adolescents. The present study aims to investigate alterations of whole-brain functional network using resting-state fMRI and graph theory analysis. We recruited 16 prelingually deaf adolescents (10 similar to 18 years) and 16 normal controls matched in age and gender. Brain networks were constructed from mean time courses of 90 regions. Widely distributed network was observed in deaf subjects, with increased connectivity between the limbic system and regions involved in visual and language processing, suggesting reinforcement of the processing for the visual and verbal information in deaf adolescents. Decreased connectivity was detected between the visual regions and language regions possibly due to inferior reading or speaking skills in deaf subjects. Using graph theory analysis, we demonstrated small-worldness property did not change in prelingually deaf adolescents relative to normal controls. However, compared with healthy adolescents, eight regions involved in visual, language, and auditory processing were identified as hubs only present in prelingually deaf adolescents. These findings revealed reorganization of brain functional networks occurred in prelingually deaf adolescents to adapt to deficient auditory input.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	CORTICAL THICKNESS ANALYSIS ; GRAPH-THEORETICAL ANALYSIS ; SUPERIOR TEMPORAL GYRUS ; VOXEL-BASED MORPHOMETRY ; INFERIOR FRONTAL GYRUS ; SMALL-WORLD NETWORKS ; VISUAL-CORTEX ; SIGN-LANGUAGE ; ADULTS ; SCHIZOPHRENIA
收录类别	SCI
语种	英语
WOS记录号	WOS:000368880300001
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/10674]
专题	自动化研究所_复杂系统管理与控制国家重点实验室_影像分析与机器视觉团队
作者单位	1.Beijing Univ Technol, Coll Elect Informat & Control Engn, Beijing 100124, Peoples R China 2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, Beijing 100190, Peoples R China 3.Beijing Key Lab Computat Intelligence & Intellige, Beijing 100124, Peoples R China 4.Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing 100730, Peoples R China 5.Capital Med Univ, Beijing Friendship Hosp, Dept Radiol, Beijing 100050, Peoples R China
推荐引用方式 GB/T 7714	Li, Wenjing,Li, Jianhong,Wang, Jieqiong,et al. Functional Reorganizations of Brain Network in Prelingually Deaf Adolescents[J]. NEURAL PLASTICITY,2016.
APA	Li, Wenjing.,Li, Jianhong.,Wang, Jieqiong.,Zhou, Peng.,Wang, Zhenchang.,...&He, Huiguang.(2016).Functional Reorganizations of Brain Network in Prelingually Deaf Adolescents.NEURAL PLASTICITY.
MLA	Li, Wenjing,et al."Functional Reorganizations of Brain Network in Prelingually Deaf Adolescents".NEURAL PLASTICITY (2016).