Emerging antitumor applications of extracellularly reengineered polymeric nanocarriers

	Emerging antitumor applications of extracellularly reengineered polymeric nanocarriers
	Chen,Jinjin; Ding,Jianxun; Xiao,Chunsheng; Zhuang,Xiuli; Chen,Xuesi
刊名	biomaterials science
	2015
卷号	3 期号:7 页码:988-1001
关键词	INTRACELLULAR DRUG-DELIVERY CANCER-THERAPY DOXORUBICIN DELIVERY GOLD NANOPARTICLES TISSUE PENETRATION IN-VITRO PH MICELLES LIPOSOMES SYSTEMS
通讯作者	chen,jj
英文摘要	recently, polymeric nanocarriers with shielding surfaces, e.g., poly(ethylene glycol) and small molecules, have been widely applied in antitumor drug delivery mainly because of their stealth during blood circulation. however, the shielding shell greatly hinders the tumor penetration, drug release, and cell internalization of the nanocarriers, which leads to unsatisfactory therapeutic efficacy. to integrate the extended blood circulation time and the enhanced drug transmission in one platform, some extracellularly stimuli-mediated shell-sheddable polymeric nanocarriers have been exploited. the systems are stealthy and stable during blood circulation, and as soon as they reach tumor tissue, the shielding matrices are removed, which is triggered by extracellular endogenous stimuli (e.g., ph or enzymes) or exogenous excitations (e.g., light or voltage). this review mainly focuses on recent advances in the designs and emerging antitumor applications of extracellularly reengineered polymeric nanocarriers for directional drug delivery, as well as perspectives for future developments.
收录类别	SCI
语种	英语
公开日期	2016-05-31
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/67872]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Chen,Jinjin,Ding,Jianxun,Xiao,Chunsheng,et al. Emerging antitumor applications of extracellularly reengineered polymeric nanocarriers[J]. biomaterials science,2015,3(7):988-1001.
APA	Chen,Jinjin,Ding,Jianxun,Xiao,Chunsheng,Zhuang,Xiuli,&Chen,Xuesi.(2015).Emerging antitumor applications of extracellularly reengineered polymeric nanocarriers.biomaterials science,3(7),988-1001.
MLA	Chen,Jinjin,et al."Emerging antitumor applications of extracellularly reengineered polymeric nanocarriers".biomaterials science 3.7(2015):988-1001.