Fe2O3@Au core@shell nanoparticle-graphene nanocomposites as theranostic agents for bioimaging and chemo-photothermal synergistic therapy

	Fe2O3@Au core@shell nanoparticle-graphene nanocomposites as theranostic agents for bioimaging and chemo-photothermal synergistic therapy
	Chen,Hongbo; Liu,Fuyao; Lei,Zhen; Ma,Lina; Wang,Zhenxin
刊名	rsc advances
	2015
卷号	5 期号:103 页码:84980-84987
关键词	PHOTODYNAMIC CANCER-THERAPY DRUG-DELIVERY MAGNETIC-RESONANCE HYBRID NANOPARTICLES MESOPOROUS SILICA GOLD NANOSHELLS OXIDE TUMOR CELLS NANOMATERIALS
通讯作者	ma,ln
英文摘要	herein, we present the synthesis and application of a new type of graphene-based magnetic and plasmonic nanocomposite for magnetic-field-assisted drug delivery and chemo-photothermal synergistic therapy. the nanocomposites were prepared via conjugation of the pegylated fe2o3@au core/shell nanoparticles (fe2o3@au nps) with reduced graphene oxide (rgo). the hybrid nanostructures (rgo-fe2o3@au nps) are superparamagnetic and show great photothermal conversion efficiency under 808 nm near-infrared (nir) laser irradiation and high drug loading ability (1.0 mg mg(-1)). mtt cell viability assay demonstrates that the chemotherapeutic drug, doxorubicin loaded rgo-fe2o3@au nps (dox-rgo-fe2o3@au nps) have synergistic interaction between photothermal therapy (ptt) and chemotherapy. furthermore, in vitro studies using hela cells show that the chemo-photothermal therapeutic efficacy of dox-rgo-fe2o3@au nps can be dramatically improved by the assistance of magnetic-field-guided drug delivery.
收录类别	SCI
语种	英语
公开日期	2016-05-31
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/67862]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Chen,Hongbo,Liu,Fuyao,Lei,Zhen,et al. Fe2O3@Au core@shell nanoparticle-graphene nanocomposites as theranostic agents for bioimaging and chemo-photothermal synergistic therapy[J]. rsc advances,2015,5(103):84980-84987.
APA	Chen,Hongbo,Liu,Fuyao,Lei,Zhen,Ma,Lina,&Wang,Zhenxin.(2015).Fe2O3@Au core@shell nanoparticle-graphene nanocomposites as theranostic agents for bioimaging and chemo-photothermal synergistic therapy.rsc advances,5(103),84980-84987.
MLA	Chen,Hongbo,et al."Fe2O3@Au core@shell nanoparticle-graphene nanocomposites as theranostic agents for bioimaging and chemo-photothermal synergistic therapy".rsc advances 5.103(2015):84980-84987.