Multifunctional polyelectrolyte multilayers coated onto Gd2O3:Yb3+,Er3+@MSNs can be used as drug carriers and imaging agents

	Multifunctional polyelectrolyte multilayers coated onto Gd2O3:Yb3+,Er3+@MSNs can be used as drug carriers and imaging agents
	Huang,Shanshan; Cheng,Ziyong; Chen,Yinyin; Liu,Bei; Deng,Xiaoran; Ma,Ping'an; Lin,Jun
刊名	rsc advances
	2015
卷号	5 期号:52 页码:41985-41993
关键词	MESOPOROUS SILICA NANOPARTICLES CORE-SHELL STRUCTURE MAGNETIC-RESONANCE IN-SITU DELIVERY PROPERTIES RELEASE DOXORUBICIN LUMINESCENCE FABRICATION TUMOR
通讯作者	lin,j
英文摘要	mesoporous silica nanoparticles (msns) were firstly functionalized with upconversion luminescent gd2o3:yb3+, er3+ via the pechini sol-gel method. then, polyelectrolyte multilayers (pem) composed of poly(allyamine hydrochloride) (pah) and poly(styrene sulfonate) (pss) were coated onto the gd2o3:yb3+, er3+@msns using a layer-by-layer (lbl) technique to achieve the ph-responsive properties of the nanocarriers. pem@gd2o3:yb3+, er3+@msns loaded with doxorubicin hydrochloride (dox) showed ph-responsive release and higher cytotoxicity towards mcf-7 breast cancer cells in vitro. nanocomposites functionalized with gd2o3:yb3+, er3+ can serve as t-1-weighted magnetic resonance imaging (mri) contrast agents. nanoparticles emitting red signals under 980 nm laser excitation are suitable for use in potential bioimaging applications. the upconversion luminescent (ucl) intensity of pem-coated nanocomposites can be adjusted by controlling the number of layers of the pah/pss coating. the pem@gd2o3:yb3+, er3+@msns can be used as a potential drug delivery system for mri, ucl imaging, and ph-responsive chemotherapy.
收录类别	SCI
语种	英语
公开日期	2016-05-31
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/67844]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Huang,Shanshan,Cheng,Ziyong,Chen,Yinyin,et al. Multifunctional polyelectrolyte multilayers coated onto Gd2O3:Yb3+,Er3+@MSNs can be used as drug carriers and imaging agents[J]. rsc advances,2015,5(52):41985-41993.
APA	Huang,Shanshan.,Cheng,Ziyong.,Chen,Yinyin.,Liu,Bei.,Deng,Xiaoran.,...&Lin,Jun.(2015).Multifunctional polyelectrolyte multilayers coated onto Gd2O3:Yb3+,Er3+@MSNs can be used as drug carriers and imaging agents.rsc advances,5(52),41985-41993.
MLA	Huang,Shanshan,et al."Multifunctional polyelectrolyte multilayers coated onto Gd2O3:Yb3+,Er3+@MSNs can be used as drug carriers and imaging agents".rsc advances 5.52(2015):41985-41993.