cRGD targeted and charge conversion-controlled release micelles for doxorubicin delivery

	cRGD targeted and charge conversion-controlled release micelles for doxorubicin delivery
	Guan,Xingang; Hu,Xiuli; Li,Zhizhong; Zhang,Hong; Xie,Zhigang
刊名	rsc advances
	2015
卷号	5 期号:29 页码:22957-22964
关键词	ENHANCED ANTITUMOR EFFICACY DRUG-DELIVERY CANCER-THERAPY TRIBLOCK COPOLYMER POLYMERIC MICELLES TUMOR VASCULATURE NANOPARTICLES THERAPEUTICS CISPLATIN PRODRUG
通讯作者	xie,zg
英文摘要	efficiently and selectively delivering chemotherapeutic agents to tumours still remains a challenge for the development of nanocarriers. in this study, polymer micelles based on crgd targeting and ph-sensitive surface charge-switching were successfully prepared and used for doxorubicin (dox) delivery. this nanoscale polymeric micelle indicated a high drug encapsulation efficiency of 90% and slightly negative charge. drug release experiments showed a ph-enhanced release profile in pbs, which resulted from surface charge-switching by imidazole. confocal laser scanning microscopy and flow cytometry experiments indicated that combining the capability of an rgd target and ph-sensitive charge-switching significantly enhanced the cellular uptake of b16f10 cells overexpressing alpha(v)beta(3) integrins. an mtt assay also showed that our hybrid rgd-decorated micelles were much more cytotoxic to b16f10 cells than undecorated micelles. these results suggest the potential application of a crgd target and ph-sensitive surface charge-switching polymeric micelles in the treatment of alpha(v)beta(3) integrin-overexpressing cancers.
收录类别	SCI
语种	英语
WOS记录号	WOS:000350643700080
公开日期	2016-05-31
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/67824]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Guan,Xingang,Hu,Xiuli,Li,Zhizhong,et al. cRGD targeted and charge conversion-controlled release micelles for doxorubicin delivery[J]. rsc advances,2015,5(29):22957-22964.
APA	Guan,Xingang,Hu,Xiuli,Li,Zhizhong,Zhang,Hong,&Xie,Zhigang.(2015).cRGD targeted and charge conversion-controlled release micelles for doxorubicin delivery.rsc advances,5(29),22957-22964.
MLA	Guan,Xingang,et al."cRGD targeted and charge conversion-controlled release micelles for doxorubicin delivery".rsc advances 5.29(2015):22957-22964.