Thiadiazole molecules and poly(ethylene glycol)-block-polylactide self-assembled nanoparticles as effective photothermal agents

	Thiadiazole molecules and poly(ethylene glycol)-block-polylactide self-assembled nanoparticles as effective photothermal agents
	Sun,Tingting; Qi,Ji; Zheng,Min; Xie,Zhigang; Wang,Zhiyuan; Jing,Xiabin
刊名	colloids and surfaces b-biointerfaces
	2015
卷号	136 页码:201-206
关键词	CONJUGATED POLYMER NANOPARTICLES REDUCED GRAPHENE OXIDE VIVO CANCER-THERAPY CELLS IN-VIVO POLYPYRROLE NANOPARTICLES FACILE PREPARATION THERANOSTIC APPLICATIONS BIOMEDICAL APPLICATIONS CONVERSION EFFICIENCY ORGANIC NANOPARTICLES
通讯作者	zheng,m
英文摘要	a new photothermal nano-agent was obtained by the coprecipitation of 2,5-bis(2,5-bis(2-thienyl)-n-dodecyl pyrrole) thieno[3,4-b][1,2,5] thiadiazole (tpt-tt) and a biodegradable amphiphilic block copolymer, methoxypoly(ethylene glycol)(2k)-block-poly(d,l-lactide)(2k) (mpeg(2k)-pdlla(2k)). tpt-tt, a donor-acceptor-donor (d-a-d) type small molecule, with bis(2-thienyl)-n-alkylpyrrole (tpt) as the donor and thieno[3,4-b]thiadiazole (tt) as the acceptor was a strong near infrared (nir) absorber, which could convert the absorbed light energy into heat. the formation of tpt-tt nanoparticles (tpt-nps), which possessed high stability in water, was confirmed by dynamic light scattering (dls) and transmission electron microscopy (tem). tpt-nps showed high photothermal conversion efficiency (32%) and excellent photostability and heating reproducibility. the photostability of tpt-tt nps was much better than that of indocyanine green (icg), a federal drug administration (fda) approved nir dye. besides, tpt-tt nps exhibited significant photothermal therapeutic effect toward human cervical carcinoma (hela) and human liver hepatocellular carcinoma (hepg2) cells, while no appreciable dark cytotoxicity was observed. these results highlight the potential of tpt-tt nps as an effective photothermal agent for cancer therapy. (c) 2015 elsevier b.v. all rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000367408100026
公开日期	2016-05-31
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/65178]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Sun,Tingting,Qi,Ji,Zheng,Min,et al. Thiadiazole molecules and poly(ethylene glycol)-block-polylactide self-assembled nanoparticles as effective photothermal agents[J]. colloids and surfaces b-biointerfaces,2015,136:201-206.
APA	Sun,Tingting,Qi,Ji,Zheng,Min,Xie,Zhigang,Wang,Zhiyuan,&Jing,Xiabin.(2015).Thiadiazole molecules and poly(ethylene glycol)-block-polylactide self-assembled nanoparticles as effective photothermal agents.colloids and surfaces b-biointerfaces,136,201-206.
MLA	Sun,Tingting,et al."Thiadiazole molecules and poly(ethylene glycol)-block-polylactide self-assembled nanoparticles as effective photothermal agents".colloids and surfaces b-biointerfaces 136(2015):201-206.