Controllable synthesis of polydopamine nanoparticles in microemulsions with pH-activatable properties for cancer detection and treatment

	Controllable synthesis of polydopamine nanoparticles in microemulsions with pH-activatable properties for cancer detection and treatment
	Liu,Fuyao; He,Xiuxia; Zhang,Junping; Chen,Hongda; Zhang,Huimao; Wang,Zhenxin
刊名	journal of materials chemistry b
	2015
卷号	3 期号:33 页码:6731-6739
关键词	IN-VIVO BIODISTRIBUTION MAGNETIC-RESONANCE SILICA NANOPARTICLES HYBRID NANOPARTICLES FACILE PREPARATION CONTRAST AGENT MRI THERAPY SIZE ENDOCYTOSIS
通讯作者	zhang,hm
英文摘要	polydopamine nanoparticles (pda nps) which combine diagnostic and therapeutic functions are potentially useful in biomedicine. however, it is difficult to synthesize pda nps of a relatively small size (<= 50 nm in diameter) using the traditional polymerization of dopamine monomers in an alkaline water-ethanol solution at room temperature. herein, pda nps with average diameters ranging from 25 nm to 43 nm are prepared in a way which is similar to the silica-like reverse microemulsion process. the size of the pda nps can be modulated by changing the amount of dopamine monomers in the microemulsion. after conjugation with ferric ions (fe3+), the poly(ethylene glycol) modified fe-pda nps (termed as peg-fe-pda nps) exhibited ph-activatable magnetic resonance imaging (mri) contrast and high photothermal performance. the combination of a small dimension and the ph-activatable mri contrast can greatly facilitate tumor accumulation and increase the tumor imaging sensitivity against animal models in vivo. completely inhibited tumor growth was achieved by the peg-fe-pda nps mediated by photothermal therapy with mri guidance.
收录类别	SCI
语种	英语
WOS记录号	WOS:000359460100002
公开日期	2016-05-31
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/65083]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Liu,Fuyao,He,Xiuxia,Zhang,Junping,et al. Controllable synthesis of polydopamine nanoparticles in microemulsions with pH-activatable properties for cancer detection and treatment[J]. journal of materials chemistry b,2015,3(33):6731-6739.
APA	Liu,Fuyao,He,Xiuxia,Zhang,Junping,Chen,Hongda,Zhang,Huimao,&Wang,Zhenxin.(2015).Controllable synthesis of polydopamine nanoparticles in microemulsions with pH-activatable properties for cancer detection and treatment.journal of materials chemistry b,3(33),6731-6739.
MLA	Liu,Fuyao,et al."Controllable synthesis of polydopamine nanoparticles in microemulsions with pH-activatable properties for cancer detection and treatment".journal of materials chemistry b 3.33(2015):6731-6739.