Biodegradable dextran vesicles for effective haemoglobin encapsulation

	Biodegradable dextran vesicles for effective haemoglobin encapsulation
	Wang,Weiqi; Liu,Shi; Huang,Yubin; Jing,Xiabin; Xie,Zhigang
刊名	journal of materials chemistry b
	2015
卷号	3 期号:28 页码:5753-5759
关键词	ARTIFICIAL OXYGEN CARRIERS DRUG-DELIVERY BOVINE HEMOGLOBIN BLOOD SUBSTITUTES PH PARTICLES MICELLES CAPSULES POLYMERS CELLS
通讯作者	xie,zg
英文摘要	biodegradable dextran vesicles were developed based on dextran and poly(l-lactide) (pla). the amphiphilic graft copolymer dextran-g-poly(l-lactide) (dextran-g-pla) was obtained by coupling carboxyl-terminated pla to dextran. the copolymer was induced to self-assemble to form nanoparticles using a dialysis procedure. the morphology and size of the nanoparticles were examined by transmission electron microscopy (tem) and dynamic light scattering (dls). an alternative morphology could be induced by varying the relative mass ratio of dextran to pla. the vesicles produced showed high stability. in order to encapsulate haemoglobin (hb), the lyophilized dextran-g-pla was dispersed in a hb phosphate buffer solution (pbs) and free hb removed by centrifugation. the oxygen affinity of haemoglobin vesicles (hbvs) was close to that of pure hb, suggesting that hbvs have considerable future potential as a blood substitute.
收录类别	SCI
语种	英语
WOS记录号	WOS:000357830600011
公开日期	2016-05-31
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/65082]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Wang,Weiqi,Liu,Shi,Huang,Yubin,et al. Biodegradable dextran vesicles for effective haemoglobin encapsulation[J]. journal of materials chemistry b,2015,3(28):5753-5759.
APA	Wang,Weiqi,Liu,Shi,Huang,Yubin,Jing,Xiabin,&Xie,Zhigang.(2015).Biodegradable dextran vesicles for effective haemoglobin encapsulation.journal of materials chemistry b,3(28),5753-5759.
MLA	Wang,Weiqi,et al."Biodegradable dextran vesicles for effective haemoglobin encapsulation".journal of materials chemistry b 3.28(2015):5753-5759.