Concise Redox Deracemization of Secondary and Tertiary Amines with a Tetrahydroisoquinoline Core via a Nonenzymatic Process

	Concise Redox Deracemization of Secondary and Tertiary Amines with a Tetrahydroisoquinoline Core via a Nonenzymatic Process
	Ji, Yue 1; Shi, Lei 1,2; Chen, Mu-Wang 1; Feng, Guang-Shou 1; Zhou, Yong-Gui 1
刊名	journal of the american chemical society
	2015-08-26
卷号	137 期号:33 页码:10496-10499
英文摘要	a concise deracemization of racemic secondary and tertiary amines with a tetrahydroisoquinoline core has been successfully realized by orchestrating a redox process consisted of n-bromosuccinimide oxidation and iridum-catalyzed asymmetric hydrogenation. this compatible redox combination enables one-pot, single-operation deracemization to generate chiral 1-substituted 1,2,3,4-tetrahydroisoquinolines with up to 98% ee in 93% yield, offering a simple and scalable synthetic technique for chiral amines directly from racemic starting materials.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, multidisciplinary
研究领域[WOS]	chemistry
关键词[WOS]	dynamic kinetic resolution ; iridium-catalyzed hydrogenation ; tandem biocatalytic oxidation ; asymmetric allylic alkylation ; substituted carboxylic-acids ; microbial deracemization ; enantioselective hydrogenation ; one-pot ; alcohols ; deracemisation
收录类别	SCI
语种	英语
WOS记录号	WOS:000360321100014
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/146497]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China 2.Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China
推荐引用方式 GB/T 7714	Ji, Yue,Shi, Lei,Chen, Mu-Wang,et al. Concise Redox Deracemization of Secondary and Tertiary Amines with a Tetrahydroisoquinoline Core via a Nonenzymatic Process[J]. journal of the american chemical society,2015,137(33):10496-10499.
APA	Ji, Yue,Shi, Lei,Chen, Mu-Wang,Feng, Guang-Shou,&Zhou, Yong-Gui.(2015).Concise Redox Deracemization of Secondary and Tertiary Amines with a Tetrahydroisoquinoline Core via a Nonenzymatic Process.journal of the american chemical society,137(33),10496-10499.
MLA	Ji, Yue,et al."Concise Redox Deracemization of Secondary and Tertiary Amines with a Tetrahydroisoquinoline Core via a Nonenzymatic Process".journal of the american chemical society 137.33(2015):10496-10499.