Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae | |
Zhang, Jingxiao1; Li, Yan1; Chen, Su-Shing2,3; Zhang, Lilei4; Wang, Jinghui1; Yang, Yinfeng1; Zhang, Shuwei1; Pan, Yanqiu1; Wang, Yonghua5; Yang, Ling6 | |
刊名 | international journal of molecular sciences |
2015-02-01 | |
卷号 | 16期号:2页码:2913-2941 |
英文摘要 | inflammation is a hallmark of many diseases like diabetes, cancers, atherosclerosis and arthritis. thus, lots of concerns have been raised toward developing novel anti-inflammatory agents. many alternative herbal medicines possess excellent anti-inflammatory properties, yet their precise mechanisms of action are yet to be elucidated. here, a novel systems pharmacology approach based on a large number of chemical, biological and pharmacological data was developed and exemplified by a probe herb folium eriobotryae, a widely used clinical anti-inflammatory botanic drug. the results show that 11 ingredients of this herb with favorable pharmacokinetic properties are predicted as active compounds for anti-inflammatory treatment. in addition, via systematic network analyses, their targets are identified to be 43 inflammation-associated proteins including especially cox2, alox5, pparg, tnf and rela that are mainly involved in the mitogen-activated protein kinase (mapk) signaling pathway, the rheumatoid arthritis pathway and nf-kappa b signaling pathway. all these demonstrate that the integrated systems pharmacology method provides not only an effective tool to illustrate the anti-inflammatory mechanisms of herbs, but also a new systems-based approach for drug discovery from, but not limited to, herbs, especially when combined with further experimental validations. |
WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
类目[WOS] | biochemistry & molecular biology ; chemistry, multidisciplinary |
研究领域[WOS] | biochemistry & molecular biology ; chemistry |
关键词[WOS] | nf-kappa-b ; traditional chinese medicine ; japonica thunb. lindl. ; inflammatory diseases ; chlorogenic acid ; drug discovery ; ursolic acid ; oral bioavailability ; therapeutic targets ; chronic-bronchitis |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000350333600038 |
公开日期 | 2016-05-09 |
内容类型 | 期刊论文 |
源URL | [http://cas-ir.dicp.ac.cn/handle/321008/146032] |
专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
作者单位 | 1.Dalian Univ Technol, Key Lab Ind Ecol & Environm Engn MOE, Fac Chem Environm & Biol Sci & Technol, Dalian 116024, Peoples R China 2.Univ Florida, Syst Biol Lab, Gainesville, FL 32608 USA 3.Univ Florida, Dept Elect & Comp Engn, Gainesville, FL 32608 USA 4.Hubei Univ Nationalities, Sch Chem & Environm Engn, Enshi 445000, Peoples R China 5.Northwest A&F Univ, Coll Life Sci, Ctr Bioinformat, Yangling 712100, Peoples R China 6.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Jingxiao,Li, Yan,Chen, Su-Shing,et al. Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae[J]. international journal of molecular sciences,2015,16(2):2913-2941. |
APA | Zhang, Jingxiao.,Li, Yan.,Chen, Su-Shing.,Zhang, Lilei.,Wang, Jinghui.,...&Yang, Ling.(2015).Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae.international journal of molecular sciences,16(2),2913-2941. |
MLA | Zhang, Jingxiao,et al."Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae".international journal of molecular sciences 16.2(2015):2913-2941. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论