Copper-Mediated Intramolecular Oxidative C-H/C-H Cross-Coupling of alpha-Oxo Ketene N,S-Acetals for Indole Synthesis

	Copper-Mediated Intramolecular Oxidative C-H/C-H Cross-Coupling of alpha-Oxo Ketene N,S-Acetals for Indole Synthesis
	Huang, Fei 1; Wu, Ping 1; Wang, Liandi 1; Chen, Jiping 1; Sun, Chenglin 1; Yu, Zhengkun 1,2
刊名	journal of organic chemistry
	2014-11-07
卷号	79 期号:21 页码:10553-10560
英文摘要	cucl2-mediated intramolecular c-h/c-h cross-dehydrogenative coupling (cdc) of thioalkyl-substituted a-acetyl or alpha-aroyl ketene n,s-acetals afforded 2-thioalkyl indoles. tunable c-s bond transformations of the resultant indoles led to highly functionalized n-heterocyclic compounds. a beta-thioalkyl is necessary to activate the n,s-acetal substrate and enable the cdc reaction to occur, and the relevant mechanism studies revealed that the cdc reaction follows a radical pathway.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, organic
研究领域[WOS]	chemistry
关键词[WOS]	n-aryl enamines ; bond activation ; cyclization ; anilines ; efficient ; functionalization ; heterocycles ; annulation ; catalysis ; oxidant
收录类别	SCI ; IC
语种	英语
WOS记录号	WOS:000344638200056
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/145747]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Huang, Fei,Wu, Ping,Wang, Liandi,et al. Copper-Mediated Intramolecular Oxidative C-H/C-H Cross-Coupling of alpha-Oxo Ketene N,S-Acetals for Indole Synthesis[J]. journal of organic chemistry,2014,79(21):10553-10560.
APA	Huang, Fei,Wu, Ping,Wang, Liandi,Chen, Jiping,Sun, Chenglin,&Yu, Zhengkun.(2014).Copper-Mediated Intramolecular Oxidative C-H/C-H Cross-Coupling of alpha-Oxo Ketene N,S-Acetals for Indole Synthesis.journal of organic chemistry,79(21),10553-10560.
MLA	Huang, Fei,et al."Copper-Mediated Intramolecular Oxidative C-H/C-H Cross-Coupling of alpha-Oxo Ketene N,S-Acetals for Indole Synthesis".journal of organic chemistry 79.21(2014):10553-10560.