Structural characterisation of algae Costaria costata fucoidan and its effects on CCl4-induced liver injury

	Structural characterisation of algae Costaria costata fucoidan and its effects on CCl4-induced liver injury
	Wang, Qiukuan 1; Song, Yuefan 1; He, Yunhai 1; Ren, Dandan 1; Kow, Felicia 2; Qiao, Zhiyong 1; Liu, Shu 1; Yu, Xingju 3
刊名	carbohydrate polymers
	2014-07-17
卷号	107 页码:247-254
关键词	Costaria costata Fucoidan Structural characterisation Liver injury
英文摘要	fucoidan is a well-known natural product that is commonly found in brown algae and shows a variety of activities, including immunomodulation, antioxidation, and the combat of carcinogens. the fucoidan fractions of costaria costata, a brown algae introduced from japan and cultured in northern china, were studied. the fucoidan fractions were extracted, separated, and purified using a combinatorial procedure consisting of enzymolysis, ethanol precipitation, and deae and size-exclusion chromatographies. the fundamental characteristics of the four enriched fucoidan fractions (f1-f4), such as their sulphate content and monosaccharide composition, were investigated. ftir and nmr spectroscopy were employed to further elucidate the structural features of the four fractions. it was found that the f1-f4 fractions all showed oxidative activity against hydroxyl radicals. the bioactive effects of the fucoidan fractions on ccl4-induced liver injury suggest their potential use as ingredients for functional foods or pharmaceuticals. (c) 2014 elsevier ltd. all rights reserved.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, applied ; chemistry, organic ; polymer science
研究领域[WOS]	chemistry ; polymer science
关键词[WOS]	brown seaweed ; laminaria-japonica ; sulfated polysaccharides ; undaria-pinnatifida ; antioxidant activity ; antitumor-activity ; in-vitro ; anticoagulant ; sporophyll ; fractions
收录类别	SCI
语种	英语
WOS记录号	WOS:000335103900032
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/145525]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Dalian Ocean Univ, Key Lab Aquat Prod Proc & Utilisat Leaning Prov, Dalian 116023, Peoples R China 2.Australian Maritime Coll, Launceston, Tas 7250, Australia 3.Chinese Acad Sci, Dalian Inst Chem Phys, Marine Bioprod Engn Grp, Beijing 100864, Peoples R China
推荐引用方式 GB/T 7714	Wang, Qiukuan,Song, Yuefan,He, Yunhai,et al. Structural characterisation of algae Costaria costata fucoidan and its effects on CCl4-induced liver injury[J]. carbohydrate polymers,2014,107:247-254.
APA	Wang, Qiukuan.,Song, Yuefan.,He, Yunhai.,Ren, Dandan.,Kow, Felicia.,...&Yu, Xingju.(2014).Structural characterisation of algae Costaria costata fucoidan and its effects on CCl4-induced liver injury.carbohydrate polymers,107,247-254.
MLA	Wang, Qiukuan,et al."Structural characterisation of algae Costaria costata fucoidan and its effects on CCl4-induced liver injury".carbohydrate polymers 107(2014):247-254.