A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography

	A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography
	Qiao, Lizhen; Wang, Shuangyuan; Li, Hua; Shan, Yuanhong; Dou, Abo; Shi, Xianzhe; Xu, Guowang
刊名	journal of chromatography a
	2014-09-19
卷号	1360 期号:1 页码:240-247
关键词	Glucaminium-based ionic liquid Hydrophilic interaction chromatography Anion-exchange Stationary phase
通讯作者	石先哲 ; 许国旺
英文摘要	glucaminium-based ionic liquids are a new class of recently developed ionic liquids and prepared by functionalizing the amine group of n-methyl-d-glucamine, which renders them good hydrophilicity due to the presence of the glucose structure and charged quaternary ammonium group. in the present study, a glucaminium-based ionic liquid n,n-diallyl-n-methyl-d-glucaminium bromide was synthesized and subsequently bonded to the surface of 3-mercaptopropyl modified silica materials through "thiol-ene" click chemistry. the obtained stationary phase was characterized by elemental analysis and infrared spectroscopy, and then packed as a hplc column. a mixture of five nucleosides was used to characterize the separation performance of the obtained column under hilic mode and the column efficiency was determined with cytidine as the test solute, reaching 80,000 plates/m. then, the retention behavior was evaluated by investigating the effect of various chromatographic factors on retention of different types of solutes, and the results revealed that the developed surface-confined glucaminium-based ionic liquid stationary phase exhibited a hydrophilic interaction/anion-exchange mixed-mode retention mechanism. finally, two mixtures of nucleotides and flavonoids were separated on the glucaminium-based ionic liquid column, respectively under hydrophilic interaction and hydrophilic interaction/anion-exchange mixed-mode chromatography. in conclusion, the multimodal retention capabilities of the glucaminium-based ionic liquid column could offer a wider range of retention behavior and flexible selectivity toward polar and hydrophilic compounds. (c) 2014 elsevier b.v. all rights reserved.
学科主题	物理化学
WOS标题词	science & technology ; life sciences & biomedicine ; physical sciences
类目[WOS]	biochemical research methods ; chemistry, analytical
研究领域[WOS]	biochemistry & molecular biology ; chemistry
关键词[WOS]	solvation energy relationships ; reversed-phase ; phenolic-acids ; separation ; performance ; retention ; selectivity ; extraction ; flavonoids ; chemistry
收录类别	SCI
语种	英语
WOS记录号	WOS:000341469400025
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/144488]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Qiao, Lizhen,Wang, Shuangyuan,Li, Hua,et al. A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography[J]. journal of chromatography a,2014,1360(1):240-247.
APA	Qiao, Lizhen.,Wang, Shuangyuan.,Li, Hua.,Shan, Yuanhong.,Dou, Abo.,...&Xu, Guowang.(2014).A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography.journal of chromatography a,1360(1),240-247.
MLA	Qiao, Lizhen,et al."A novel surface-confined glucaminium-based ionic liquid stationary phase for hydrophilic interaction/anion-exchange mixed-mode chromatography".journal of chromatography a 1360.1(2014):240-247.