Development of a novel imidazolium-based aromatic quaternary ammonium tag: Synthesis and application to the efficient analysis of cysteinyl-peptides by mass spectrometry
Qiao, Xiaoqiang1,2; Wang, Rui1,2,3; Yan, Hongyuan1,2; Wang, Tao1,2; Zhao, Qun3; Zhang, Lihua3; Zhang, Yukui3
刊名rapid communications in mass spectrometry
2014-02-15
卷号28期号:3页码:256-264
通讯作者乔晓强 ; 张丽华
英文摘要rationalechemical derivatization is a very promising technique for improving analysis of peptides by mass spectrometry (ms). in this study, a novel kind of imidazolium-based aromatic quaternary ammonium tag, 1-[3-[(2-iodo-1-oxoethyl)amino]propyl]-3-butylimidazolium bromide (ipbi), designed with strong gas-phase basicity and a permanent positive charge, was firstly synthesized and further used for derivatization of cysteinyl-peptides with improved ionization efficiency and higher charge states.
学科主题物理化学
WOS标题词science & technology ; life sciences & biomedicine ; physical sciences ; technology
类目[WOS]biochemical research methods ; chemistry, analytical ; spectroscopy
研究领域[WOS]biochemistry & molecular biology ; chemistry ; spectroscopy
关键词[WOS]electron-transfer dissociation ; carboxy group derivatization ; n-terminal derivatization ; maldi-tof ms ; chemical derivatization ; signal enhancement ; bottom-up ; liquid ; phosphopeptides ; ionization
收录类别SCI
语种英语
WOS记录号WOS:000328823200003
公开日期2016-05-09
内容类型期刊论文
源URL[http://cas-ir.dicp.ac.cn/handle/321008/144440]  
专题大连化学物理研究所_中国科学院大连化学物理研究所
作者单位1.Hebei Univ, Key Lab Pharmaceut Qual Control Hebei Prov, Baoding 071002, Peoples R China
2.Hebei Univ, Coll Pharmaceut Sci, Baoding 071002, Peoples R China
3.Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714
Qiao, Xiaoqiang,Wang, Rui,Yan, Hongyuan,et al. Development of a novel imidazolium-based aromatic quaternary ammonium tag: Synthesis and application to the efficient analysis of cysteinyl-peptides by mass spectrometry[J]. rapid communications in mass spectrometry,2014,28(3):256-264.
APA Qiao, Xiaoqiang.,Wang, Rui.,Yan, Hongyuan.,Wang, Tao.,Zhao, Qun.,...&Zhang, Yukui.(2014).Development of a novel imidazolium-based aromatic quaternary ammonium tag: Synthesis and application to the efficient analysis of cysteinyl-peptides by mass spectrometry.rapid communications in mass spectrometry,28(3),256-264.
MLA Qiao, Xiaoqiang,et al."Development of a novel imidazolium-based aromatic quaternary ammonium tag: Synthesis and application to the efficient analysis of cysteinyl-peptides by mass spectrometry".rapid communications in mass spectrometry 28.3(2014):256-264.
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