Synergistic inhibitory effect of Icariside II with Icaritin from Herba Epimedii on pre-osteoclastic RAW264.7 cell growth

	Synergistic inhibitory effect of Icariside II with Icaritin from Herba Epimedii on pre-osteoclastic RAW264.7 cell growth
	Liu, Yan-Qiu 1,2; Yang, Qian-Xu 2; Cheng, Meng-Chun 2; Xiao, Hong-Bin 2,3
刊名	phytomedicine
	2014-10-15
卷号	21 期号:12 页码:1633-1637
关键词	Herba Epimedii Icaritin Icariside II RAW264.7 Synergy
通讯作者	肖红斌
英文摘要	increasing evidence shows the therapeutic superiority of herbal extracts in comparison to isolated single constituents. one of the reasons may be attributed to the synergy effect of compound combinations. flavonoids from herba epimedii have been shown to have therapeutic effect against bone loss. our previous study showed that icariside ii inhibited pre-osteoclast raw264.7 growth. the aim of this study was to investigate whether the activity of icariside ii is synergized by other components of herba epimedii. the inhibitory activity of icariside ii was significantly enhanced in the presence of the extract of herba epimedii (ehe) at the ratio of 1:1, 1:5 and 1:10. icaritin, another flavonoid constituent, was shown here to inhibit raw264.7 growth in a dose-dependent manner. further, we found that icariside ii, together with icaritin, synergistically inhibited raw264.7 growth. the synergistic effect is significant when the ratio of icariside ii and icaritin was 10:1, 5:1, 1:1, 1:2, and 1:5, respectively. in conclusion, icaritin were an active component. the inhibitory activity of icariside ii on pre-osteoclast raw264.7 growth was synergized by icaritin, which maybe contribute to the efficiency of herba epimedii extract on curing bone-related diseases, such as osteoporosis (c) 2014 elsevier gmbh. all rights reserved.
学科主题	物理化学
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	plant sciences ; chemistry, medicinal ; integrative & complementary medicine ; pharmacology & pharmacy
研究领域[WOS]	plant sciences ; pharmacology & pharmacy ; integrative & complementary medicine
关键词[WOS]	total flavonoids ; koreanum nakai ; in-vitro ; glycosides ; differentiation ; proliferation ; osteoporosis ; targets ; lines
收录类别	SCI
语种	英语
WOS记录号	WOS:000344241200016
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/144162]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Dalian Med Univ, Coll Inst Integrat Med, Dalian 116044, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 3.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yan-Qiu,Yang, Qian-Xu,Cheng, Meng-Chun,et al. Synergistic inhibitory effect of Icariside II with Icaritin from Herba Epimedii on pre-osteoclastic RAW264.7 cell growth[J]. phytomedicine,2014,21(12):1633-1637.
APA	Liu, Yan-Qiu,Yang, Qian-Xu,Cheng, Meng-Chun,&Xiao, Hong-Bin.(2014).Synergistic inhibitory effect of Icariside II with Icaritin from Herba Epimedii on pre-osteoclastic RAW264.7 cell growth.phytomedicine,21(12),1633-1637.
MLA	Liu, Yan-Qiu,et al."Synergistic inhibitory effect of Icariside II with Icaritin from Herba Epimedii on pre-osteoclastic RAW264.7 cell growth".phytomedicine 21.12(2014):1633-1637.