Macrocyclic Diterpenoids from the Latex of Euphorbia helioscopia

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Macrocyclic Diterpenoids from the Latex of Euphorbia helioscopia
	Hua, Juan 1,2; Liu, Yan-Chun1 ; Jing, Shu-Xi 1; Luo, Shi-Hong 1; Li, Sheng-Hong1
刊名	NATURAL PRODUCT COMMUNICATIONS
	2015-12-01
卷号	10 期号:12 页码:2037-2039
关键词	Euphorbia helioscopia Latex Jatrophane diterpenoid Lathyrane diterpenoid Anti-inflammatory activity
英文摘要	One new jatrophane diterpenoid, 7 alpha,9 beta,15 beta-triacetoxy-3 beta-benzoyloxy-14 beta-hydroxyjatropha-5E,11E-diene (3), together with four known macrocyclic diterpenoids, euphoheliosnoid A (1), epieuphoscopin B (2), euphohelioscopin A (4) and euphoscopin C (5), were isolated from the stem latex of Eziphorbia helioscopia. Their structures were established by spectroscopic analyses. In the anti-inflammatory assay, euphohelioscopin A (4) exhibited moderate inhibitory activity on the release of cytokine TNF-alpha (IC50 = 23.7 +/- 1.7 mu M), IL-6 (IC50 = 46.1 +/- mu M) and chemokine MCP-1 (IC50 = 33.7 +/- 3.8 mu M) in lipopolysaccharide (LPS) induced RAW 264.7 macrophages without notable cytotoxicity (IC50 > 80 mu M).
类目[WOS]	Chemistry, Medicinal ; Food Science & Technology
研究领域[WOS]	Pharmacology & Pharmacy ; Food Science & Technology
收录类别	SCI
语种	英语
WOS记录号	WOS:000367211300009
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/25433]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Hua, Juan,Liu, Yan-Chun,Jing, Shu-Xi,et al. Macrocyclic Diterpenoids from the Latex of Euphorbia helioscopia[J]. NATURAL PRODUCT COMMUNICATIONS,2015,10(12):2037-2039.
APA	Hua, Juan,Liu, Yan-Chun,Jing, Shu-Xi,Luo, Shi-Hong,&Li, Sheng-Hong.(2015).Macrocyclic Diterpenoids from the Latex of Euphorbia helioscopia.NATURAL PRODUCT COMMUNICATIONS,10(12),2037-2039.
MLA	Hua, Juan,et al."Macrocyclic Diterpenoids from the Latex of Euphorbia helioscopia".NATURAL PRODUCT COMMUNICATIONS 10.12(2015):2037-2039.