Gold-Nanoparticle-Based Multifunctional Amyloid-beta Inhibitor against Alzheimer's Disease

	Gold-Nanoparticle-Based Multifunctional Amyloid-beta Inhibitor against Alzheimer's Disease
	Gao,Nan; Sun,Hanjun; Dong,Kai; Ren,Jinsong; Qu,Xiaogang
刊名	chemistry-a european journal
	2015
卷号	21 期号:2 页码:829-835
关键词	DAWSON-TYPE POLYOXOTUNGSTATES PROTEIN FIBRILLATION WELLS-DAWSON PEPTIDE AGGREGATION BINDING AGENTS COPPER WATER
通讯作者	qu,xg
英文摘要	targeting amyloid-beta (a beta)-induced complex neurotoxicity has received considerable attention in the therapeutic and preventive treatment of alzheimer's disease (ad). the complex pathogenesis of ad suggests that it requires comprehensive treatment, and drugs with multiple functions against ad are more desirable. herein, aunps@pomd-pep (aunps: gold nanoparticles, pomd: polyoxometalate with wells-dawson structure, pep: peptide) were designed as a novel multifunctional a beta inhibitor. aunps@pomd-pep shows synergistic effects in inhibiting a beta aggregation, dissociating a beta fibrils and decreasing a beta-mediated peroxidase activity and a beta-induced cytotoxicity. by taking advantage of aunps as vehicles that can cross the blood-brain barrier (bbb), aunps@pomd-pep can cross the bbb and thus overcome the drawbacks of small-molecule anti-ad drugs. thus, this work provides new insights into the design and synthesis of inorganic nanoparticles as multifunctional therapeutic agents for treatment of ad.
收录类别	SCI
语种	英语
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64822]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Gao,Nan,Sun,Hanjun,Dong,Kai,et al. Gold-Nanoparticle-Based Multifunctional Amyloid-beta Inhibitor against Alzheimer's Disease[J]. chemistry-a european journal,2015,21(2):829-835.
APA	Gao,Nan,Sun,Hanjun,Dong,Kai,Ren,Jinsong,&Qu,Xiaogang.(2015).Gold-Nanoparticle-Based Multifunctional Amyloid-beta Inhibitor against Alzheimer's Disease.chemistry-a european journal,21(2),829-835.
MLA	Gao,Nan,et al."Gold-Nanoparticle-Based Multifunctional Amyloid-beta Inhibitor against Alzheimer's Disease".chemistry-a european journal 21.2(2015):829-835.