Breaking of the Phosphodiester Bond: A Key Factor That Induces Hemolysis

	Breaking of the Phosphodiester Bond: A Key Factor That Induces Hemolysis
	Wang,Tiantian; Jiang,Xiue
刊名	acs applied materials & interfaces
	2015
卷号	7 期号:1 页码:129-136
关键词	TRANSFORM INFRARED-SPECTROSCOPY QUANTUM DOTS ADENOSINE-TRIPHOSPHATE HUMAN ERYTHROCYTES FTIR SPECTROSCOPY PROTEIN MONOLAYER CDTE NANOCRYSTALS SHAPE CONTROL NANOPARTICLES CELL
通讯作者	jiang,xe
英文摘要	in-depth understanding the toxicity of nanomaterials in red blood cells (rbcs) is of great interest, because of the importance of rbcs in transporting oxygen in blood circulation. although the toxic effects of nanoparticles in rbcs have been revealed, the conclusions from the literature are conflicting, and in particular, the toxic mechanism is still at the infant stage. herein, we investigated the size-dependent toxicity of well-known cdte semiconductor quantum dots (qds) and revealed the exact toxic mechanism at the molecular level by confocal microscopy and fourier transform infrared (ft-ir) spectroscopy techniques. we found that smaller mercaptosuccinic acid-capped cdte qds (msa-qds) with the green-emitting color could cause hemagglutination whereas the middle-size yellow-emitting msa-qds induced the formation of stomatocytes and echinocytes and the bigger size red-emitting msa-qds induced heavy hemolysis and the formation of lots of ghost cells. the ft-ir data proved that all the msa-qds were likely to bond to the rbcs membranes and caused the structural changes of lipid and protein in rbcs. but only the red-emitting msa-qds caused the breakage of the phosphodiester bond, which might cause the heavy hemolysis. to some extent, this is the first example that reveals the hemolysis mechanism at the molecular level.
收录类别	SCI
语种	英语
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64736]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Wang,Tiantian,Jiang,Xiue. Breaking of the Phosphodiester Bond: A Key Factor That Induces Hemolysis[J]. acs applied materials & interfaces,2015,7(1):129-136.
APA	Wang,Tiantian,&Jiang,Xiue.(2015).Breaking of the Phosphodiester Bond: A Key Factor That Induces Hemolysis.acs applied materials & interfaces,7(1),129-136.
MLA	Wang,Tiantian,et al."Breaking of the Phosphodiester Bond: A Key Factor That Induces Hemolysis".acs applied materials & interfaces 7.1(2015):129-136.