Unexpected high photothemal conversion efficiency of gold nanospheres upon grafting with two-photon luminescent ruthenium(II) complexes: A way towards cancer therapy?

	Unexpected high photothemal conversion efficiency of gold nanospheres upon grafting with two-photon luminescent ruthenium(II) complexes: A way towards cancer therapy?
	Zhang, Pingyu 1; Wang, Jinquan 1; Huang, Huaiyi 1; Yu, Bole 1; Qiu, Kangqiang 1; Huang, Juanjuan 1; Wang, Shutao 2; Jiang, Lei 3; Gasser, Gilles 4; Ji, Liangnian 1
刊名	BIOMATERIALS
	2015-09-01
卷号	63 页码:102-114
关键词	Photothermal Two-photon luminescence Ru(II) complex Gold nanospheres
英文摘要	The design and development of functional hybrid nanomaterials is currently a topic of great interest in biomedicine. Herein we investigated the grafting of Ru(II) polypyridyl complexes onto gold nanospheres (Ru@AuNPs) to improve the particles' near infrared (NIR) absorption, and ultimately allow for application in photothermal cancer therapy. As demonstrated in this article, these ruthenium(II) complexes could indeed significantly enhance gold nanospheres' two-photon luminescence (PTL) intensity and photothermal therapy (PIT) efficiency. The best dual functional nanoparticles of this study were successfully used for real-time luminescent imaging-guided PIT in live cancer cells. Furthermore, in vivo tumor ablation was achieved with excellent treatment efficacy under a diode laser (808 nm) irradiation at the power density of 0.8 W/cm(2) for 5 min. This study demonstrates that the coupling of inert Ru(II) polypyridyl complexes to gold nanospheres allows for the enhancement of two-photon luminescence and for efficient photothermal effect. (C) 2015 Elsevier Ltd. All rights reserved.
收录类别	SCI
语种	英语
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/27834]
专题	化学研究所_有机固体实验室
作者单位	1.Sun Yat Sen Univ, Sch Chem & Chem Engn, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China 2.Chinese Acad Sci, Tech Inst Phys & Chem, Lab Bioinspired Smart Interface Sci, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Chem, Key Lab Organ Solid, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 4.Univ Zurich, Dept Chem, CH-8057 Zurich, Switzerland
推荐引用方式 GB/T 7714	Zhang, Pingyu,Wang, Jinquan,Huang, Huaiyi,et al. Unexpected high photothemal conversion efficiency of gold nanospheres upon grafting with two-photon luminescent ruthenium(II) complexes: A way towards cancer therapy?[J]. BIOMATERIALS,2015,63:102-114.
APA	Zhang, Pingyu.,Wang, Jinquan.,Huang, Huaiyi.,Yu, Bole.,Qiu, Kangqiang.,...&Chao, Hui.(2015).Unexpected high photothemal conversion efficiency of gold nanospheres upon grafting with two-photon luminescent ruthenium(II) complexes: A way towards cancer therapy?.BIOMATERIALS,63,102-114.
MLA	Zhang, Pingyu,et al."Unexpected high photothemal conversion efficiency of gold nanospheres upon grafting with two-photon luminescent ruthenium(II) complexes: A way towards cancer therapy?".BIOMATERIALS 63(2015):102-114.