Tuning the singlet-triplet energy gap: a unique approach to efficient photosensitizers with aggregation-induced emission (AIE) characteristics

	Tuning the singlet-triplet energy gap: a unique approach to efficient photosensitizers with aggregation-induced emission (AIE) characteristics
	Xu, Shidang 1; Yuan, Youyong 1; Cai, Xiaolei 1; Zhang, Chong-Jing 1; Hu, Fang 2; Liang, Jing 1; Zhang, Guanxin 2; Zhang, Deqing 2; Liu, Bin 1,3
刊名	CHEMICAL SCIENCE
	2015
卷号	6 期号:10 页码:5824-5830
英文摘要	The efficiency of the intersystem crossing process can be improved by reducing the energy gap between the singlet and triplet excited states (Delta E-ST), which offers the opportunity to improve the yield of the triplet excited state. Herein, we demonstrate that modulation of the excited states is also an effective strategy to regulate the singlet oxygen generation of photosensitizers. Based on our previous studies that photosensitizers with aggregation-induced emission characteristics (AIE) showed enhanced fluorescence and efficient singlet oxygen production in the aggregated state, a series of AIE fluorogens such as TPDC, TPPDC and PPDC were synthesized, which showed DEST values of 0.48, 0.35 and 0.27 eV, respectively. A detailed study revealed that PPDC exhibited the highest singlet oxygen efficiency (0.89) as nanoaggregates, while TPDC exhibited the lowest efficiency (0.28), inversely correlated with their DEST values. Due to their similar optical properties, TPDC and PPDC were further encapsulated into nanoparticles (NPs). Subsequent surface modification with cell penetrating peptide (TAT) yielded TAT-TPDC NPs and TAT-PPDC NPs. As a result of the stronger singlet oxygen generation, TAT-PPDC NPs showed enhanced cancer cell ablation as compared to TAT-TPDC NPs. Fine-tuning of the singlet-triplet energy gap is thus proven to be an effective new strategy to generate efficient photosensitizers for photodynamic therapy.
收录类别	SCI
语种	英语
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/27637]
专题	化学研究所_有机固体实验室
作者单位	1.Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117585, Singapore 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Organ Solids Lab, Beijing 100190, Peoples R China 3.Inst Mat Res & Engn, Singapore 117602, Singapore
推荐引用方式 GB/T 7714	Xu, Shidang,Yuan, Youyong,Cai, Xiaolei,et al. Tuning the singlet-triplet energy gap: a unique approach to efficient photosensitizers with aggregation-induced emission (AIE) characteristics[J]. CHEMICAL SCIENCE,2015,6(10):5824-5830.
APA	Xu, Shidang.,Yuan, Youyong.,Cai, Xiaolei.,Zhang, Chong-Jing.,Hu, Fang.,...&Liu, Bin.(2015).Tuning the singlet-triplet energy gap: a unique approach to efficient photosensitizers with aggregation-induced emission (AIE) characteristics.CHEMICAL SCIENCE,6(10),5824-5830.
MLA	Xu, Shidang,et al."Tuning the singlet-triplet energy gap: a unique approach to efficient photosensitizers with aggregation-induced emission (AIE) characteristics".CHEMICAL SCIENCE 6.10(2015):5824-5830.