Molecular Engineering of Aqueous Soluble Triarylboron-Compound-Based Two-Photon Fluorescent Probe for Mitochondria H2S with Analyte-Induced Finite Aggregation and Excellent Membrane Permeability

	Molecular Engineering of Aqueous Soluble Triarylboron-Compound-Based Two-Photon Fluorescent Probe for Mitochondria H2S with Analyte-Induced Finite Aggregation and Excellent Membrane Permeability
	Liu, Jun 1; Guo, Xudong 1; Hu, Rui 1; Liu, Xinyang 2; Wang, Shuangqing 1; Li, Shayu 1; Li, Yi 2; Yang, Guoqiang 1
刊名	ANALYTICAL CHEMISTRY
	2016-01-05
卷号	88 期号:1 页码:1052-1057
英文摘要	Hydrogen sulfide (H2S) is a multifunctional signaling molecule that participates in many important biological processes. Herein, by functionalizing triarylboron with cyclen and diphenylamine, we synthesized TAB-1, TAB-2, and TAB-3 for H2S recongnization by rational design of molecular structures. Among them, aqueous soluble TAB-2 possesses excellent properties, including large two-photon action cross section, membrane permeability and can effectively complex with Cu2+ The complex of TAB-2-Cu2+ can selectively detect H2S with an instant response and mitochondria targeted. Moreover, the H2S-induced finite aggregation of indicators enhances their photostability and causes variation of the fluorescence lifetime. TAB-2-Cu2+ has also been successfully applied for the mitochondria H2S imaging in NIH/3T3 fibroblast cells by TPM and FLIM.
收录类别	SCI
语种	英语
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/29776]
专题	化学研究所_光化学实验室
作者单位	1.Chinese Acad Sci, Inst Chem, Key Lab Photochem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jun,Guo, Xudong,Hu, Rui,et al. Molecular Engineering of Aqueous Soluble Triarylboron-Compound-Based Two-Photon Fluorescent Probe for Mitochondria H2S with Analyte-Induced Finite Aggregation and Excellent Membrane Permeability[J]. ANALYTICAL CHEMISTRY,2016,88(1):1052-1057.
APA	Liu, Jun.,Guo, Xudong.,Hu, Rui.,Liu, Xinyang.,Wang, Shuangqing.,...&Yang, Guoqiang.(2016).Molecular Engineering of Aqueous Soluble Triarylboron-Compound-Based Two-Photon Fluorescent Probe for Mitochondria H2S with Analyte-Induced Finite Aggregation and Excellent Membrane Permeability.ANALYTICAL CHEMISTRY,88(1),1052-1057.
MLA	Liu, Jun,et al."Molecular Engineering of Aqueous Soluble Triarylboron-Compound-Based Two-Photon Fluorescent Probe for Mitochondria H2S with Analyte-Induced Finite Aggregation and Excellent Membrane Permeability".ANALYTICAL CHEMISTRY 88.1(2016):1052-1057.