Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer's disease

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	Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer's disease
	Wang, Shao-wei 1; Yang, Shi-gao 1; Liu, Wen 1,2; Zhang, Yang-xin 1,2; Xu, Peng-xin 1,3; Wang, Teng 1,2; Ling, Tie-jun 4; Liu, Rui-tian 1
刊名	BEHAVIOURAL BRAIN RESEARCH
	2016
卷号	296 期号:JAN 页码:109-117
关键词	RRR-alpha-tocopherol quinine Alzheimer's disease Beta-amyloid oligomer Neuroinflammation NF-kappa B signaling Oxidative stress
ISSN号	0166-4328
英文摘要	The pathologies of Alzheimer's disease (AD) is associated with soluble beta-amyloid (A beta) oligomers, neuroinflammation and oxidative stress. Decreasing the levels of A beta oligomer, glial activation and oxidative stress are potential therapeutic approaches for AD treatment. We previously found alpha-tocopherol quinine (alpha-TQ) inhibited Ap aggregation and cytotoxicity, decreased the release of inflammatory cytokines and reactive oxygen species (ROS) in vitro. However, whether alpha-TQameliorates memory deficits and other neuropathologies in mice or patients with AD remains unknown. In this study, we reported that orally administered a-TQ ameliorated memory impairment in APPswe/PS1dE9 transgenic mice, decreased oxidative stress and the levels of A beta oligomer in the brains of mice, prevented the production of inducible nitric oxide synthase and inflammatory mediators, such as interleukin-6 and interleukin-1 beta, and inhibited microglial activation by inhibiting NF-kappa B signaling pathway. These findings suggest that alpha-TQ has potential therapeutic value for AD treatment. (C) 2015 Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Behavioral Sciences ; Neurosciences
研究领域[WOS]	Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]	NF-KAPPA-B ; NEURODEGENERATIVE DISEASE ; IN-VIVO ; FIBRILS ; QUINONE ; CONFORMATION ; INFLAMMATION ; SUPEROXIDE ; PROTEIN ; MITOCHONDRIA
收录类别	SCI
语种	英语
WOS记录号	WOS:000366079100015
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/20144]
专题	过程工程研究所_生化工程国家重点实验室
作者单位	1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 2.Anhui Agr Univ, Sch Life Sci, Hefei 230036, Peoples R China 3.Ningxia Univ, Sch Life Sci, Yinchuan 750021, Peoples R China 4.Anhui Agr Univ, State Key Lab Tea Plant Biol & Utilizat, Hefei 230036, Peoples R China
推荐引用方式 GB/T 7714	Wang, Shao-wei,Yang, Shi-gao,Liu, Wen,et al. Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer's disease[J]. BEHAVIOURAL BRAIN RESEARCH,2016,296(JAN):109-117.
APA	Wang, Shao-wei.,Yang, Shi-gao.,Liu, Wen.,Zhang, Yang-xin.,Xu, Peng-xin.,...&Liu, Rui-tian.(2016).Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer's disease.BEHAVIOURAL BRAIN RESEARCH,296(JAN),109-117.
MLA	Wang, Shao-wei,et al."Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer's disease".BEHAVIOURAL BRAIN RESEARCH 296.JAN(2016):109-117.