QQ客服 官方微博 反馈留言

题名	遗忘型轻度认知损伤患者情节记忆的功能成像模式： 一个激活似然性评估元分析
作者	黄 昕
学位类别	硕士
答辩日期	2015-05
授予单位	中国科学院研究生院
授予地点	北京
导师	李娟
关键词	遗忘型轻度认知损伤 情节记忆 编码 提取 激活似然性评估
其他题名	Functional Imaging Patterns of Episodic Memory in Amnesic Mild Cognitive Impairment: an Activation Likelihood Estimation Meta-analysis
学位专业	心理学
中文摘要	目的：遗忘型轻度认知损伤(aMCI)被视为正常老化和临床痴呆之间的过渡阶段。任务相关的脑功能成像技术越来越多地被应用于 aMCI情节记忆方面的研究。然而，关于aMCI在记忆编码和提取过程中内侧颞叶(MTL)和前额皮质的激活模式，诸多相关研究的结论并不一致。本研究尝试通过一个定量的元分析，总体评估从单个研究中无法得出的一致性激活模式。方法：使用激活似然性评估（ALE）这一方法，分析对比 aMCI与正常对照组在情节记忆编码和提取阶段的激活可能性区域。我们对aMCI任务相关神经功能影像研究进行了全面的文件检索（文章发表日期截止至2015 年3月31日），共有符合入组标准文献 24篇，包括 770个激活坐标（foci） 。结果： 与健康对照组相比，aMCI情节记忆脑激活模式出现大面积异常，不仅在双侧内侧颞叶以及前额皮质，此外还涉及角回，楔前叶，后扣带回，甚至一些最原始的脑结构，如丘脑、梭状回、楔叶等。结论：本研究运用ALE元分析技术，总结和揭示了aMCI情节记忆领域不同研究间的一致性结论，结果进一步支持aMCI患者“名不副实”，其脑功能受损情况十分严重。 Introduction:  Amnesic  mild cognitive impairment (aMCI) is considered as a transitional stage between normal aging and clinical dementia. Task-related functional brain imaging techniques are increasingly being used to examine episodic memory function among individuals with aMCI. However, findings are inconsistent regarding activity within the medial temporal lobe (MTL) and frontal cortex during both encoding and retrieval processes across several studies. The present study thus conducts a quantitative meta-analysis to assess consensus across this important research area and elucidate consistent activation patterns that might not be readily apparent just by examining individual studies. Methods:  An activation likelihood estimation (ALE) meta-analysis was conducted on studies of episodic memory encoding and retrieval processes in aMCI with control group comparisons. The ALE analysis was based on a thorough literature search for all task-related functional neuro-imaging studies in aMCI published up to March 31, 2015. The analysis included 24 studies, which yielded 770 distinct foci. Results: Compared to healthy controls, individuals with aMCI  demonstrated an abnormal pattern in a widespread episodic memory network, not only in the bilateral MTL and prefrontal cortex, but also in the angular gyrus, precunes, posterior cingulate cortex, and even some more basic structures 目的：遗忘型轻度认知损伤(aMCI)被视为正常老化和临床痴呆之间的过渡阶段。任务相关的脑功能成像技术越来越多地被应用于 aMCI情节记忆方面的研究。然而，关于aMCI在记忆编码和提取过程中内侧颞叶(MTL)和前额皮质的激活模式，诸多相关研究的结论并不一致。本研究尝试通过一个定量的元分析，总体评估从单个研究中无法得出的一致性激活模式。方法：使用激活似然性评估（ALE）这一方法，分析对比 aMCI与正常对照组在情节记忆编码和提取阶段的激活可能性区域。我们对aMCI任务相关神经功能影像研究进行了全面的文件检索（文章发表日期截止至2015 年3月31日），共有符合入组标准文献 24篇，包括 770个激活坐标（foci） 。结果： 与健康对照组相比，aMCI情节记忆脑激活模式出现大面积异常，不仅在双侧内侧颞叶以及前额皮质，此外还涉及角回，楔前叶，后扣带回，甚至一些最原始的脑结构，如丘脑、梭状回、楔叶等。结论：本研究运用ALE元分析技术，总结和揭示了aMCI情节记忆领域不同研究间的一致性结论，结果进一步支持aMCI患者“名不副实”，其脑功能受损情况十分严重。
英文摘要	Introduction:  Amnesic  mild cognitive impairment (aMCI) is considered as a transitional stage between normal aging and clinical dementia. Task-related functional brain imaging techniques are increasingly being used to examine episodic memory function among individuals with aMCI. However, findings are inconsistent regarding activity within the medial temporal lobe (MTL) and frontal cortex during both encoding and retrieval processes across several studies. The present study thus conducts a quantitative meta-analysis to assess consensus across this important research area and elucidate consistent activation patterns that might not be readily apparent just by examining individual studies. Methods:  An activation likelihood estimation (ALE) meta-analysis was conducted on studies of episodic memory encoding and retrieval processes in aMCI with control group comparisons. The ALE analysis was based on a thorough literature search for all task-related functional neuro-imaging studies in aMCI published up to March 31, 2015. The analysis included 24 studies, which yielded 770 distinct foci. Results: Compared to healthy controls, individuals with aMCI  demonstrated an abnormal pattern in a widespread episodic memory network, not only in the bilateral MTL and prefrontal cortex, but also in the angular gyrus, precunes, posterior cingulate cortex, and even some more basic structures such as the thalamus, fusiform gyrus, and cuneus. Conclusion: The present ALE meta-analysis reveals that certain findings were consistent among individuals with aMCI across the episodic memory literature and laboratories. The results further support that individuals with mild cognitive impairment may not be completely “mild” in nature.
语种	中文
学科主题	基础心理学
内容类型	学位论文
源URL	[http://ir.psych.ac.cn/handle/311026/19595]
专题	心理研究所_健康与遗传心理学研究室
作者单位	中国科学院心理研究所
推荐引用方式 GB/T 7714	黄 昕. 遗忘型轻度认知损伤患者情节记忆的功能成像模式： 一个激活似然性评估元分析[D]. 北京. 中国科学院研究生院. 2015.

个性服务

查看访问统计

相关权益政策

暂无数据

收藏/分享

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。