Enhanced Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells on Graphene Oxide-Incorporated Electrospun Poly(lactic-co-glycolic acid) Nanofibrous Mats

CORC > 苏州纳米技术与纳米仿生研究所 > 中国科学院苏州纳米技术与纳米仿生研究所 > 纳米生物医学与安全研究部 > 张智军团队

	Enhanced Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells on Graphene Oxide-Incorporated Electrospun Poly(lactic-co-glycolic acid) Nanofibrous Mats
	Luo, Y; Shen, H(沈贺); Fang, YX; Cao, YH(曹玉华); Huang, J; Zhang, MX(张萌欣); Dai, JW(戴建武); Shi, XY; Zhang, ZJ(张智军)
刊名	ACS APPLIED MATERIALS & INTERFACES
	2015
卷号	7 期号:11 页码:9
关键词	nanofibrous mat electrospinning graphene oxide mesenchymal stem cells osteogenic differentiation tissue engineering
通讯作者	Dai, JW (戴建武)
英文摘要	Currently, combining biomaterial scaffolds with living stem cells for tissue regeneration is a main approach for tissue engineering. Mesenchymal stem cells (MSCs) are promising candidates for musculoskeletal tissue repair through differentiating into specific tissues, such as bone, muscle, and cartilage. Thus, successfully directing the fate of MSCs through factors and inducers would improve regeneration efficiency. Here, we report the fabrication of graphene oxide (GO)-doped poly(lactic-co-glycolic acid) (PLGA) nanofiber scaffolds via electrospinning technique for the enhancement of osteogenic differentiation of MSCs. GO-PLGA nanofibrous mats with three-dimensional porous structure and smooth surface can be readily produced via an electrospinning technique. GO plays two roles in the nanofibrous mats: first, it enhances the hydrophilic performance, and protein- and inducer-adsorption ability of the nanofibers. Second, the incorporated GO accelerates the human MSCs (hMSCs) adhesion and proliferation versus pure PLGA nanofiber and induces the osteogenic differentiation. The incorporating GO scaffold materials may find applications in tissue engineering and other fields.
收录类别	SCI
语种	英语
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.sinano.ac.cn/handle/332007/3410]
专题	苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_张智军团队
推荐引用方式 GB/T 7714	Luo, Y,Shen, H,Fang, YX,et al. Enhanced Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells on Graphene Oxide-Incorporated Electrospun Poly(lactic-co-glycolic acid) Nanofibrous Mats[J]. ACS APPLIED MATERIALS & INTERFACES,2015,7(11):9.
APA	Luo, Y.,Shen, H.,Fang, YX.,Cao, YH.,Huang, J.,...&Zhang, ZJ.(2015).Enhanced Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells on Graphene Oxide-Incorporated Electrospun Poly(lactic-co-glycolic acid) Nanofibrous Mats.ACS APPLIED MATERIALS & INTERFACES,7(11),9.
MLA	Luo, Y,et al."Enhanced Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells on Graphene Oxide-Incorporated Electrospun Poly(lactic-co-glycolic acid) Nanofibrous Mats".ACS APPLIED MATERIALS & INTERFACES 7.11(2015):9.