Ultrasmall Graphene Oxide Supported Gold Nanoparticles as Adjuvants Improve Humoral and Cellular Immunity in Mice

CORC > 苏州纳米技术与纳米仿生研究所 > 中国科学院苏州纳米技术与纳米仿生研究所 > 纳米生物医学与安全研究部 > 张智军团队

	Ultrasmall Graphene Oxide Supported Gold Nanoparticles as Adjuvants Improve Humoral and Cellular Immunity in Mice
	Zhang, ZJ (张智军); Dai, JW (戴建武)
刊名	ADVANCED FUNCTIONAL MATERIALS
	2014
卷号	24 期号:44 页码:6963-6971
关键词	gold nanoparticles biomedical applications graphene oxide cellular immunity adjuvants
通讯作者	Cao, YH (曹玉华)
英文摘要	Adjuvants play an important role in vaccines. Alum and MF59 are two dominant kinds of adjuvants used in humans. Both of them, however, have limited capacity to generate the cellular immune response required for vaccines against cancers and viral diseases. It is desirable to develop new and efficient adjuvants with the aim of improving the cellular immune response against the antigen. Here, the feasibility and efficiency of ultrasmall graphene oxide supported gold nanoparticles (usGO-Au) as a new immune adjuvant to improve immune responses are explored. usGO-Au is obtained from reduction of chloroauric acid using usGO and then decorated with ovalbumin (OVA, a model antigen) through physical adsorption to construct usGO-Au@OVA. As the results show, the as-synthesized usGO-Au@OVA can efficiently stimulate RAW264.7 cells to secrete tumor necrosis factor- (TNF-), a mediator for cellular immune response. In vivo studies demonstrate that usGO-Au@OVA can also promote robust OVA specific antibody response, CD8(+) T cells proliferation, and different cytokines secretion. The results indicate that using usGO-Au as an adjuvant can stimulate potent humoral and cellular immune responses against antigens, which may promote better understanding of cellular immune response and facilitate potential applications for cancer and viral vaccines.
收录类别	SCI
语种	英语
WOS记录号	WOS:000345370900008
公开日期	2015-02-03
内容类型	期刊论文
源URL	[http://ir.sinano.ac.cn/handle/332007/1827]
专题	苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_张智军团队
推荐引用方式 GB/T 7714	Zhang, ZJ ,Dai, JW . Ultrasmall Graphene Oxide Supported Gold Nanoparticles as Adjuvants Improve Humoral and Cellular Immunity in Mice[J]. ADVANCED FUNCTIONAL MATERIALS,2014,24(44):6963-6971.
APA	Zhang, ZJ ,&Dai, JW .(2014).Ultrasmall Graphene Oxide Supported Gold Nanoparticles as Adjuvants Improve Humoral and Cellular Immunity in Mice.ADVANCED FUNCTIONAL MATERIALS,24(44),6963-6971.
MLA	Zhang, ZJ ,et al."Ultrasmall Graphene Oxide Supported Gold Nanoparticles as Adjuvants Improve Humoral and Cellular Immunity in Mice".ADVANCED FUNCTIONAL MATERIALS 24.44(2014):6963-6971.